Registration Dossier
Registration Dossier
Data platform availability banner - registered substances factsheets
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 204-822-2 | CAS number: 127-08-2
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Eye irritation
Administrative data
- Endpoint:
- eye irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- From 1990-07-02 to 1990-09-03
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: Study according to OECD guideline, with GLP compliance.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 990
- Report date:
- 1990
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 405 (Acute Eye Irritation / Corrosion)
- Deviations:
- no
- GLP compliance:
- yes
Test material
- Reference substance name:
- Potassium acetate
- EC Number:
- 204-822-2
- EC Name:
- Potassium acetate
- Cas Number:
- 127-08-2
- Molecular formula:
- C2H4O2.K
- IUPAC Name:
- potassium acetate
- Details on test material:
- - Name of test material (as cited in study report): Safeway KA, LP 1848 (50 % water solution of Potassium acetate)
- Molecular formula (if other than submission substance): CH3COO-K+
- Molecular weight (if other than submission substance): 1,28 kg/L
- Analytical purity: 50,1% Potassium acetate
- Impurities (identity and concentrations): 0,10% Tolyltriazol; 0,05% H3PO4; rest water till 100%.
- Purity test date: 1990-07-16
- Lot/batch No.: Hoe CG 0255 OA ZD50 0001
- Storage condition of test material: 20 ºC (in dark)
Constituent 1
Test animals / tissue source
- Species:
- rabbit
- Strain:
- New Zealand White
- Details on test animals or tissues and environmental conditions:
- TEST ANIMALS
- Source: Hoechst AG,
- Age at study initiation: 3-5 months
- Weight at study initiation: 3.4 - 4.1 kg
- Diet (e.g. ad libitum): Altromin 2123 (ca. 15 g/day)
- Water (e.g. ad libitum): deionized chlorinated water from automatic watering, ad libitum
- Housing:in fully air-condition, spaces in single cages
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 20 +/- 3 ºC
- Humidity (%): 50 +/- 20%
- Photoperiod (hrs dark / hrs light): 12 hours
Test system
- Vehicle:
- unchanged (no vehicle)
- Controls:
- not required
- Amount / concentration applied:
- TEST MATERIAL
- Amount(s) applied (volume or weight with unit): 0.1 mL of test substance Safeway KA - Duration of treatment / exposure:
- Duration: 24 hours.
- Observation period (in vivo):
- Observation period: 1, 24, 48 and 72 hours
- Number of animals or in vitro replicates:
- Three animals were used.
- Details on study design:
- REMOVAL OF TEST SUBSTANCE
- Washing (if done): yes, with physiologic NaCl
- Time after start of exposure: after 24 hours.
SCORING SYSTEM:
CORNEA:
Opacity: degree of turbidity (for the evaluation is the densest place genom):
0. No ulceration or opacity
1. Scattered or diffuse opacity (other than slight turbidity ofnormal luster), details of iris clearly visible
2. Easily discernible translucent area, details of iris slightly shadowed
3. Pearly areas, no details of iris visible, size of pupil barely discernible
4. Opaque cornea, iris not discernible due to the opacity
IRIS:
0.Normal
1.Extremely depth wrinkles, congestion, swelling, slight circum-corneal hyperemia or injection, any of these symptoms, or a combina tion of the various symptoms, the iris still reacts to light (sluggish reaction is positive).
2.No reaction to light, haemorrhage, severe damage (one or all symptoms)
CONJUNCTIVAE
Redness, lids and / or nictitating
0. Blood vessels normal,
1. Some blood vessels show a marked hyperemia (injection)
2. Diffuse crimson color, individual vessels not easily discernible
3. Diffuse bright
Chemosis: lids and / or nictitating
0. No swelling
1. Any swelling above normal lying (including haw)
2. Obvious swelling with partial eversion of lids
3. Swelling with lids about half closed
4. Swelling with more than half-closed lids
TOOL USED TO ASSESS SCORE: fluorescein NaCl (0.01%) examined in UV light.
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- cornea opacity score
- Basis:
- mean
- Time point:
- other: 72h
- Score:
- 0
- Max. score:
- 4
- Irritation parameter:
- iris score
- Basis:
- mean
- Time point:
- other: 72h
- Score:
- 0
- Max. score:
- 2
- Irritation parameter:
- conjunctivae score
- Basis:
- mean
- Time point:
- other: 72h
- Score:
- 1
- Max. score:
- 3
Any other information on results incl. tables
Based on the present study assessed Potassium acetate is therefore not considered to be irritating.
Applicant's summary and conclusion
- Interpretation of results:
- not irritating
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- Based on the present study assessed Potassium acetate is therefore not considered to be irritating.
- Executive summary:
An eye irritation test (72 hours) using 3 rabbits has been performed on the test substance LP 1848 (50 % water solution of Potassium acetate) in accordance with guideline OECD Guideline 405 (Acute Eye Irritation / Corrosion).
Based on the present study assessed Potassium acetate is therefore not considered to be irritating.In this test, the control parameters were within the recommended ranges based.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.