Registration Dossier
Registration Dossier
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EC number: 235-715-9 | CAS number: 12607-70-4
Endpoint summary
Administrative data
Key value for chemical safety assessment
Effects on fertility
Additional information
According to the EU C&L Dossier and the OECD SIDS draft 2007 no data is available for nickel carbonate and -hydroxide. However, based on the consistent evidence of developmental toxicity of nickel compounds (stillbirth, postimplantation / perinatal lethality) in rats at dose levels not causing maternal toxicity, nickel carbonate is classified for developmental toxicity as Repr. Cat. 2; R61 (GHS: Repr. 1B).
Fertility: No effects have been found in generation studies on nickel chloride or nickel sulphate. There is some evidence for effects on male sex organs in rats and mice (found in limited studies after oral, inhalation or subcutaneous administration of nickel chloride or - sulphate.)
Short description of key information:
Nickel carbonate hydroxide is classified according to Annex I to Directive 67/548/EEC with T / Repr. Cat. 2 / R61
Justification for classification or non-classification
Additional information
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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