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EC number: 294-415-6 | CAS number: 91722-14-4
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- July 2001
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: The study has been conducted according to OECD guideline No. 423 and under GLP.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 001
- Report date:
- 2001
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 423 (Acute Oral toxicity - Acute Toxic Class Method)
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Test type:
- acute toxic class method
- Limit test:
- yes
Test material
- Reference substance name:
- Soybean oil, epoxidized, acrylate
- EC Number:
- 294-415-6
- EC Name:
- Soybean oil, epoxidized, acrylate
- Cas Number:
- 91722-14-4
- Molecular formula:
- C63H108O15
- IUPAC Name:
- Soybean oil, epoxidized, acrylate
- Test material form:
- liquid: viscous
- Details on test material:
- - Name of test material (as cited in study report): SAT 010416 (PHOTOMER 3005 F)
- Substance type: UVCB
- Physical state: amber, middle-viscous liquid
- Analytical purity: 100%
- Impurities (identity and concentrations):
- Lot/batch No.: 9829547285
- Expiration date of the lot/batch: 21 May 2001
- Storage condition of test material: room tenperature, in the dark
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Wistar
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: SPF Wistar rats, stock Shoe WIST, Tierzucht Schönwalde GmbH, Germany
- Age at study initiation: no data
- Weight at study initiation: 142-178 g
- Fasting period before study: approximately 18 hours before dosing
- Housing: in transparent, polycarbonate cages
- Diet (e.g. ad libitum): pelleted, complete rodet diet "Altromin 1314"
- Water (e.g. ad libitum): domestic quality drinking water
- Acclimation period: at least 5 days
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 21 ± 3
- Humidity (%): 55 ± 15
- Air changes (per hr): 10
- Photoperiod (hrs dark / hrs light): 12 hrs dark/12 hours light
IN-LIFE DATES: From: To: 2 July - 20 July 2001
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- unchanged (no vehicle)
- Details on oral exposure:
- MAXIMUM DOSE VOLUME APPLIED: 10 ml/kg b.w.
- Doses:
- 5000 mg/kg
- No. of animals per sex per dose:
- 3 males, 3 females
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 1, 3 and 6 hours after administration and thereafter daily for 14 days
- Frequency of observations and weighing: body weight was recorded on days 0, 7 and 14
- Necropsy of survivors performed: yes, gross necroscy
- Other examinations performed: clinical signs, body weight,organ weights, histopathology, other:
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 5 000 mg/kg bw
- Based on:
- test mat.
- Remarks on result:
- other: not applicable
- Mortality:
- No mortailty and no marked signs of toxicity were observed.
- Clinical signs:
- other: All 3 male rats showed a pinched abdomen and piloerection 1 and 3 hours after application of the test substance. Piloerection was still seen after 6 hour and 1 day after dosing. From day 2 until the end of the observation period no abnormalities were reve
- Gross pathology:
- At gross necropsy of the animals no pathological abnormalities were observed.
Applicant's summary and conclusion
- Interpretation of results:
- not classified
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- Under the experimental conditions described in the report, the oral LD50 of the test substance in rats was higher than 5000 mg/kg b.w.
- Executive summary:
The acute oral toxicity of the test substance (SAT 01416) was determined according to the OECD guideline No. 423 "Acute Oral Toxicity - Acute Tox Class Method". The study was conducted with one group consisting of 3 male an 3 female rats, which were given a dose of 5000 mg/kg b.w.
No mortality was observed in the study. Clinical signs were diarrhoea, pinched abdomen and piloerection during the first day after dosing. Under the experimental conditions described in the report, the oral LD50 of the test substance in rats was higher than 5000 mg/kg b.w.
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