Registration Dossier
Registration Dossier
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EC number: 203-550-1 | CAS number: 108-10-1
Toxicity to aquatic algae and cyanobacteria
Administrative data
Link to relevant study record(s)
Description of key information
Key value for chemical safety assessment
- EC50 for freshwater algae:
- 146 mg/L
- EC10 or NOEC for freshwater algae:
- 146 mg/L
Additional information
A pre-test has been realized using Algae. Unfortunately based on unexpected bacterial growth the relevancy of this pre-test was considered as questionable. The pre-test has been re-done following different methodological procedures but the lab failed to implement a relevant algae test. Therefore the notifier decided to move forward with a surrogate for this test, a Lemna gibba one for which no technical difficulties occurred.
The influence of 4-methylpentan-2-one on the growth of the freshwater plant Lemna gibba was assessed in a semi-static limit-test in closed vessel design (OECD 221).
The 7-day ErC50was calculated to be > 146 mg test item/L for frond number and dry weight.
The 7-day EyC50was calculated to be > 146 mg test item/L for frond number and dry weight.
The 7-day NOErC and the LOErC were determined to be = 146 and > 146 mg test item/L, respectively.
The 7-day NOEyC and the LOEyC were determined to be = 146 and > 146 mg test item/L, respectively. Three other studies carried out by Bringmann & Kuhn during the late 70’s were not considered as relevant enough (Klimish rating of 3) but even the methodology was not sound enough the results are on line with those obtained in the 2010 report and allow to safely conclude that MIBK is not toxic or harmful to algae.Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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