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EC number: 201-279-3 | CAS number: 80-43-3
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Toxicity to reproduction: other studies
Administrative data
- Endpoint:
- toxicity to reproduction: other studies
- Type of information:
- experimental study
- Adequacy of study:
- disregarded due to major methodological deficiencies
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- other: Unsuitable test system, non-guideline study, results refer to external concentration only.
Data source
Reference
- Reference Type:
- publication
- Title:
- Embryotoxic effects of eight organic peroxides and hydrogen peroxide on three-day chicken embryos
- Author:
- Korhonen A, Hemminki K, Vainio H
- Year:
- 1 984
- Bibliographic source:
- Environmental research 33, 54-61
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- 3-day old embryos were exposed by applying the substance on the inner shell membrane in the air chamber.
- GLP compliance:
- not specified
- Type of method:
- in vivo
Test material
- Reference substance name:
- Bis(α,α-dimethylbenzyl) peroxide
- EC Number:
- 201-279-3
- EC Name:
- Bis(α,α-dimethylbenzyl) peroxide
- Cas Number:
- 80-43-3
- Molecular formula:
- C18H22O2
- IUPAC Name:
- 1,1'-(dioxydipropane-2,2-diyl)dibenzene
- Details on test material:
- - Name of test material (as cited in study report): dicumylperoxide (DICUP)
- Analytical purity: 96-99%
Supplier: Merck, Schuchardt, München
Constituent 1
Test animals
- Species:
- other: white leghorn chicken eggs
Administration / exposure
- Route of administration:
- other: inner shell membrane of air chamber
- Vehicle:
- acetone
- Analytical verification of doses or concentrations:
- no
- Duration of treatment / exposure:
- 14d
Doses / concentrations
- Remarks:
- Doses / Concentrations:
0.38, 0.75, 1.5 and 3.0
Basis:
other: µmole/egg
- No. of animals per sex per dose:
- 30
- Control animals:
- yes, concurrent vehicle
Results and discussion
Effect levels
- Dose descriptor:
- NOAEC
- Effect level:
- 0.38 other: µmole/egg
- Sex:
- not specified
- Basis for effect level:
- other: mortality, malformations
Any other information on results incl. tables
Number of early deaths (after 2d) were only about 20% (7 and 6 from 30 eggs at 1.5 and 3.0 µmole/egg, respectively). At a concentration of 3.0 µmole/egg 16 late deaths showed malformation at day 14 (53% of initial). 8 and 7 late deaths showed malformation at 0.75 and 1.5 µmole/egg, respectively.
The authors discussed that the low rate of early deats may be related to the fact that the chemicla was not lethal at the doses tested or that high lethal concentrations did not reach the embryo during teh 2 days, but lower teratogenic doses did.
Applicant's summary and conclusion
- Conclusions:
- The authors stated that all of the tested peroxides (inicluding CAS 80-43-3) are rather untoxic to the embryos (all had ED50 >100 µmole/egg), compared to other chemicals tested with ED50 values from 18 -90 nmole/egg for thiurams and 2.5 -26 nmole/egg for dithiocarbamates.
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