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EC number: 400-910-1 | CAS number: 119822-74-1
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Short-term toxicity to aquatic invertebrates
Administrative data
Link to relevant study record(s)
- Endpoint:
- short-term toxicity to aquatic invertebrates
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 10 July 1984 to 15 August 1984
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 202 (Daphnia sp. Acute Immobilisation Test)
- Deviations:
- no
- GLP compliance:
- no
- Specific details on test material used for the study:
- Test substance; FAT 20306/B
Appearance: red powder
Purity: active ingredient
Solubility: 50 g/l water
Storage: room temperature
Stability: 30 years (2014)
Stock solution: 200 mg FAT 20306/B were dissolved in water and made up to 1000 ml with water. - Analytical monitoring:
- yes
- Details on sampling:
- The test substance was dissolved at all test concentrations. Samples for analysis were taken after 0 h and 24 h exposure.
- Vehicle:
- no
- Details on test solutions:
- Test concentration: 18, 32, 58, 100, 180 mg/l (nominal)
Calculated amounts of stock solution to produce the desired test concentrations were given into the water and homogeneously distributed. - Test organisms (species):
- Daphnia magna
- Details on test organisms:
- Strain: DAPHNIA MAGNA STRAUS 1820
Source: CIBA-GEIGY Ltd., Facilities, Basle
Breeding: Parthenogenetic reproduction. Feed: Suspension of green algae supplemented by trout chow and/or powder milk and/or yeast; in such quantities that food is consumed after 24 hours.
Pretreatment: 24 hours before the start of the test reproductive daphnia are separated from the young by sieving through an 800 micrometer sieves. This operation is repeated immediately before the start and the young daphnia (0 - 24 h old) are retained for the test. - Test type:
- static
- Water media type:
- freshwater
- Limit test:
- no
- Total exposure duration:
- 24 h
- Hardness:
- 240 mg CaCO3/l
- Test temperature:
- 20 - 21 °C
- pH:
- 7.8 - 7.9
- Dissolved oxygen:
- 8.2 - 8.9 mg/l; 93 - 99 % of saturation
- Salinity:
- no data
- Nominal and measured concentrations:
- nominal: 18, 32, 58, 100, 180 mg/l
measured: 91 - 99 % of nominal - Details on test conditions:
- Vessels: 20 ml test tubes, covered with steel caps (10 ml solution)
Water: Reconstituted water produced by dissolving:
65 mg NaHC03
294 mg CaCl2•2H2O
123 mg MgS04•7H2O
6 mg KCl
in 1000 ml bidistilled water.
The water was aerated with clean air for at least 24 h before use
Controls: blank: water
Number of daphnids: 20 daphnia/conc. and control. (4 replicates of 5 daphnia)
Feeding: None during the test,
Aeration: none
Duration: 24 hours
Lighting: 16 hours fluorescent light daily, approx. 2000 lux
Measurements: (pH, O2, temperature) at the beginning and at the end of the test. - Reference substance (positive control):
- no
- Duration:
- 24 h
- Dose descriptor:
- EC50
- Effect conc.:
- 49 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mobility
- Remarks:
- calculated
- Remarks on result:
- other: 41-57 mg/l
- Duration:
- 24 h
- Dose descriptor:
- EC50
- Effect conc.:
- 54 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mobility
- Remarks:
- graphically determined
- Details on results:
- Controls : Immobilization blank 0 %
- Results with reference substance (positive control):
- no data
- Reported statistics and error estimates:
- The EC50 values were calculated according to J.EOKSON, JA5A 40(1953), 569-599, EC50 was graphically determined on gausso-logarithnic probability paper.
- Validity criteria fulfilled:
- yes
- Conclusions:
- The calculated and graphically determined 24 h EC50 of FAT 20306/B in acute daphnia test is 49 and 54 mg/L, respectively.
- Executive summary:
The test was performed to determine the EC50 (concentration where 50 % of the daphnids are immobilized) to DAPHNIA MAGNA STRAUS 1820 during 24 hours test period according to OECD test method 202. No immobilisation was found at 18 mg/L concentration group only. Based on the study results, the calculated EC50 (24h) of was 49 mg/L (confidence limit of 41-57 mg/L). The graphically determined EC50 (24 h) was 54 mg/L.
Reference
Immobilization:
Concentrations Noninal (mg/L) |
Immobilization after 24 hours |
|||||
1 |
2 |
3 |
4 |
total |
% |
|
Blank |
0 |
0 |
0 |
0 |
0 |
0 |
18 |
0 |
0 |
0 |
0 |
0 |
0 |
32 |
2 |
2 |
1 |
0 |
5 |
25 |
58 |
4 |
3 |
3 |
4 |
14 |
70 |
100 |
4 |
5 |
4 |
5 |
18 |
90 |
180 |
4 |
5 |
5 |
5 |
19 |
95 |
Description of key information
The calculated and graphically determined 24 h EC50 of FAT 20306/B in acute daphnia test is 49 and 54 mg/L, respectively.
Key value for chemical safety assessment
Fresh water invertebrates
Fresh water invertebrates
- Effect concentration:
- 49 mg/L
Additional information
The test was performed to determine the EC50 (concentration where 50 % of the daphnia are immobilized) to DAPHNIA MAGNA STRAUS 1820 during 24 hours test period according to OECD test method 202. No immobilisation was found at 18 mg/L concentration group only. Based on the study results, the calculated EC50 (24h) of was 49 mg/L (confidence limit of 41-57 mg/L). The graphically determined EC50 (24 h) was 54 mg/L.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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