Registration Dossier
Registration Dossier
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EC number: 200-860-9 | CAS number: 75-31-0
Endpoint summary
Administrative data
Link to relevant study record(s)
Description of key information
No particular data available. Isopropylamine is expected to be readily eliminated from the organism either metabolised by oxidative desamination, thus resulting in acetone, or excreted from the body in unchanged form.
Key value for chemical safety assessment
- Bioaccumulation potential:
- no bioaccumulation potential
Additional information
Isopropylamine is assumed to be readily bioavailable by all potential routes of exposure. Exposure may mainly occur by inhalation
and by skin contact. Dermal uptake may differ, depending on the application form (direct application of liquid isopropylamine, vapour exposure)
It can be concluded that ingested isopropylamine is no proper substrate of MAO, but partly may undergo methyl- or N-oxidation.
But a substantial part is expected to be excreted unchanged into the urine. If oxidative deamination occurs, acetone will be formed.
This is usually exhaled as well as excreted into the urine. Small amounts of acetone are normally formed in the intermediary metabolism through spontaneous or enzymatic decarboxylation of acetoacetate.
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Overall, isopropylamine will not accumulate and is not expected to form harmful intermediates (Cavender et al. 2000).
Thredgold et al. (2018) did not observe a relevant uptake via skin after in vitro exposure of human skin to isopropylamine vapour (3000 ppm) for 20 or 30 min. Skin penetration was < 1µg at the end of the exposure period and skin absorption < 12 µg.
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