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EC number: 203-442-4 | CAS number: 106-92-3
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Genetic toxicity: in vitro
Administrative data
- Endpoint:
- in vitro gene mutation study in bacteria
- Remarks:
- Type of genotoxicity: gene mutation
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Comparable to guideline study with acceptable restriction (missing strain for crosslinking/oxidizing agents)
Data source
Referenceopen allclose all
- Reference Type:
- publication
- Title:
- Unnamed
- Year:
- 1 990
- Reference Type:
- publication
- Title:
- Comparative mutagenicity of aliphatic epoxides in Salmonella.
- Author:
- Canter DA, Zeiger E, Haworth S, Lawlor T, Mortelmans K, Speck W
- Year:
- 1 986
- Bibliographic source:
- Mutat. Res. 172: 105-138
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 471 (Bacterial Reverse Mutation Assay)
- Deviations:
- yes
- Remarks:
- missing strain for crosslinking/oxidizing agents
- GLP compliance:
- no
- Type of assay:
- bacterial reverse mutation assay
Test material
- Reference substance name:
- Allyl 2,3-epoxypropyl ether
- EC Number:
- 203-442-4
- EC Name:
- Allyl 2,3-epoxypropyl ether
- Cas Number:
- 106-92-3
- Molecular formula:
- C6H10O2
- IUPAC Name:
- 2-[(prop-2-en-1-yloxy)methyl]oxirane
- Details on test material:
- - Name of test material (as cited in study report): Allyl Glycidyl Ether
- Physical state: clear colorless liquid
- Analytical purity: 99 %
Constituent 1
Method
- Target gene:
- his+
Species / strain
- Species / strain / cell type:
- S. typhimurium TA 1535, TA 1537, TA 98 and TA 100
- Metabolic activation:
- with and without
- Metabolic activation system:
- S9 from Aroclor 1254-induced male Sprague-Dawley rat and Syrian hamster liver
- Test concentrations with justification for top dose:
- 0, 100, 333, 1000, 3333, 10000 µg/plate
- Vehicle / solvent:
- - Vehicle(s)/solvent(s) used: DMSO
Controlsopen allclose all
- Negative solvent / vehicle controls:
- yes
- Positive controls:
- yes
- Positive control substance:
- other: 2-aminoanthracene for all strains
- Remarks:
- with S9 mix
- Negative solvent / vehicle controls:
- yes
- Positive controls:
- yes
- Positive control substance:
- other: 4-nitro-o-phenylenediamine for TA98, sodium azide for TA100 and TA1535, and 9-aminoacridine for TA1537
- Remarks:
- without S9 mix
- Details on test system and experimental conditions:
- METHOD OF APPLICATION: preincubation
DURATION
- Preincubation period: 20 minutes
METABOLIC ACTIVATION:
The test was conducted with and without metabolic activation. In this study metabolic activation enzymes and cofactors from Aroclor 1254-induced male Sprague-Dawley rat and Syrian hamster liver were used.
REPEAT STUDY: One repeat was performed for TA 100 and TA 1535. - Evaluation criteria:
- - A positive response was defined as a reproducible, dose-related increase in histidine-independent (revertant) colonies in any one strain/activation combination.
- An equivocal response was defined as an increase in revertants which was not dose related, not reproducible, or of insufficient magnitude to support a determination of mutagenicity.
- A response was considered negative when no increase in revertant colonies was observed after chemical treatment.
Results and discussion
Test resultsopen allclose all
- Species / strain:
- other: Salmonella typhimurium TA100, TA1535
- Metabolic activation:
- with and without
- Genotoxicity:
- positive
- Cytotoxicity / choice of top concentrations:
- cytotoxicity
- Remarks:
- 10000 µg/plate
- Vehicle controls validity:
- valid
- Positive controls validity:
- valid
- Species / strain:
- other: Salmonella typhimurium TA1537, TA98
- Metabolic activation:
- with and without
- Genotoxicity:
- negative
- Cytotoxicity / choice of top concentrations:
- cytotoxicity
- Remarks:
- 10000 µg/plate in TA1537, from 3333 µg/plate in TA98 without S9
- Vehicle controls validity:
- valid
- Positive controls validity:
- valid
- Additional information on results:
- TEST-SPECIFIC CONFOUNDING FACTORS
- Precipitation: No precipitation was observed at any of the doses tested
Others: Mutagenic response was observed in every positive control tested. The solvent control did not induce any mutagenic response. - Remarks on result:
- other: other: Salmonella typhimurium TA100, TA1535
- Remarks:
- Migrated from field 'Test system'.
Any other information on results incl. tables
Mean Revertants (±SE) from three plates
TA1535
Dose |
No Activation |
No Activation |
10% HLI |
10% HLI |
10% RLI |
10% RLI |
||||||
Protocol |
Preincubation |
Preincubation |
Preincubation |
Preincubation |
Preincubation |
Preincubation |
||||||
ug/Plate |
Mean |
± SEM |
Mean |
± SEM |
Mean |
± SEM |
Mean |
± SEM |
Mean |
± SEM |
Mean |
± SEM |
0 |
23 |
3.8 |
26 |
2.7 |
10 |
1.8 |
10 |
1.5 |
18 |
1.2 |
13 |
2.3 |
100 |
63 |
10.2 |
54 |
5.4 |
9 |
1.2 |
17 |
2.2 |
13 |
0.6 |
17 |
3.5 |
333 |
125 |
10.3 |
166 |
1 |
27 |
3.8 |
42 |
5.2 |
19 |
7.2 |
29 |
2.1 |
1000 |
250 |
45.1 |
347 |
9 |
119 |
9.1 |
195 |
5.7 |
49 |
9.8 |
128 |
7.2 |
3333 |
759 |
20.2 |
783 |
22 |
444 |
27.8 |
516 |
12 |
442 |
43.6 |
495 |
12.2 |
10000 |
525s |
84.6 |
1019s |
26.4 |
454s |
15.3 |
577s |
11.9 |
521 |
33.2 |
406s |
91.8 |
Positive Control |
1373 |
108.5 |
1604 |
61.8 |
115 |
13.6 |
139 |
1.7 |
119 |
0.7 |
63 |
0.6 |
TA100
Dose |
No Activation |
No Activation |
10% HLI |
10% HLI |
10% RLI |
10% RLI |
||||||
Protocol |
Preincubation |
Preincubation |
Preincubation |
Preincubation |
Preincubation |
Preincubation |
||||||
ug/Plate |
Mean |
± SEM |
Mean |
± SEM |
Mean |
± SEM |
Mean |
± SEM |
Mean |
± SEM |
Mean |
± SEM |
0 |
105 |
1.7 |
159 |
9 |
105 |
9.8 |
130 |
5.8 |
116 |
13.9 |
135 |
5.8 |
100 |
177 |
2.9 |
211 |
7.9 |
84 |
10.7 |
137 |
6.8 |
123 |
1.5 |
143 |
7.8 |
333 |
326 |
15.3 |
371 |
9 |
147 |
8.8 |
172 |
0.9 |
161 |
8.4 |
155 |
10.7 |
1000 |
904 |
198.3 |
814 |
30.5 |
329 |
14.3 |
399 |
5.8 |
382 |
13.6 |
417 |
10.5 |
3333 |
2178 |
119.4 |
2047 |
79.8 |
1382 |
21.7 |
1571 |
14.9 |
1478 |
50.1 |
1388 |
150.7 |
10000 |
3312s |
135.3 |
3431s |
15.9 |
3569 |
85.7 |
3705s |
91.3 |
3726 |
133.3 |
3654s |
63.6 |
Positive Control |
2407 |
63.5 |
2397 |
25.7 |
2160 |
50.6 |
1491 |
37 |
1125 |
41.3 |
395 |
17.1 |
TA98
Dose |
No Activation |
10% HLI |
10% RLI |
|||
Protocol |
Preincubation |
Preincubation |
Preincubation |
|||
ug/Plate |
Mean |
± SEM |
Mean |
± SEM |
Mean |
± SEM |
0 |
16 |
1.8 |
28 |
2.3 |
29 |
3.1 |
100 |
18 |
2.1 |
27 |
3.6 |
28 |
1.2 |
333 |
19 |
0.9 |
25 |
2.7 |
27 |
2 |
1000 |
18 |
1.2 |
26 |
1.5 |
31 |
5.5 |
3333 |
17s |
1.2 |
25 |
5.8 |
29 |
2.6 |
10000 |
t |
|
34 |
5.5 |
30 |
2.6 |
Positive Control |
1579 |
37.9 |
970 |
40.2 |
874 |
39.3 |
TA1537
Dose |
No Activation |
10% HLI |
10% RLI |
|||
Protocol |
Preincubation |
Preincubation |
Preincubation |
|||
ug/Plate |
Mean |
± SEM |
Mean |
± SEM |
Mean |
± SEM |
0 |
7 |
0.7 |
6 |
0 |
7 |
1 |
100 |
7 |
2.3 |
8 |
1.5 |
10 |
3.2 |
333 |
8 |
2.6 |
8 |
1 |
7 |
2.1 |
1000 |
8 |
1.3 |
11 |
2.2 |
4 |
1.5 |
3333 |
9 |
1.7 |
7 |
0.6 |
5s |
1 |
10000 |
5s |
1.2 |
11 |
0.9 |
10s |
2.4 |
Positive Control |
346 |
115 |
76 |
20.7 |
114 |
13.2 |
RLI = induced male Sprague Dawley rat liver S9
HLI = induced male Syrian hamster liver S9
s = Slight Toxicity; t = Toxic
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.