Registration Dossier
Registration Dossier
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EC number: 619-447-3 | CAS number: 99607-70-2
Solubility in organic solvents / fat solubility
Administrative data
Link to relevant study record(s)
- Endpoint:
- solubility in organic solvents / fat solubility
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1991-07-11 - 1991-12-17
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- other: internal Standard Operating Procedure
- Deviations:
- no
- Principles of method if other than guideline:
- Mixtures of the test substance with the test solvents were prepared (ensuring saturation). After centrifugation the clear solution was analysed by gas chromatography to determine the solubility of the test substance.
- GLP compliance:
- yes
- Medium:
- acetone
- Solubility:
- 340 g/L
- Temp.:
- 25 °C
- Medium:
- ethanol
- Solubility:
- 190 g/L
- Temp.:
- 25 °C
- Medium:
- other: n-hexane
- Solubility:
- 11 g/L
- Temp.:
- 25 °C
- Medium:
- n-octanol
- Solubility:
- 140 g/L
- Temp.:
- 25 °C
- Medium:
- toluene
- Solubility:
- 360 g/L
- Temp.:
- 25 °C
- Test substance stable:
- yes
- Details on results:
- The solubilities reported above have been corrected to two significant figures, and are given pro litre of saturated solution.
- Conclusions:
- The study is considered to be adequate and reliable.
- Executive summary:
The solubility in organic solvents at 25 °C was determined as 340 g/L in acetone, 190 g/L in ethanol, 11 g/L in n-hexane, 140 g/L in n-octanol and in 360 g/L in toluene.
Reference
Description of key information
Solubility in organic solvents (Rodler, 25 °C, technical grade substance):
acetone: 340 g/L
ethanol: 190 g/L
n-hexane: 11 g/L
n-octanol: 140 g/L
toluene: 360 g/L
Key value for chemical safety assessment
Additional information
The available study is considered to be reliable and adequate.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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