Cinnamaldehyde

Acute Toxicity: oral

Administrative data

Endpoint:

acute toxicity: oral

Type of information:

experimental study

Adequacy of study:

key study

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

data from handbook or collection of data

Justification for type of information:

Data is from publication

Data source

Reference

Reference 1

Reference Type:

other: authoritative database

Title:

Acute oral toxicity by using test chemical

Author:

U.S. National Library of Medicine

Year:

2018

Bibliographic source:

ChemIDplus

Reference 2

Reference Type:

other: Secondary Literature

Title:

Acute oral toxicity of test chemical in rats

Author:

RTECS

Year:

2018

Bibliographic source:

RTECS (registry of toxic effect of chemical substance data base), 2018

Reference 3

Reference Type:

other: Data is from authoritative database

Title:

Acute oral toxicity of test chemical in rat

Author:

IFA GESTIS

Year:

2018

Bibliographic source:

GESTIS Substance Database, 2018

Reference 4

Reference Type:

publication

Title:

Food Flavourings and Compounds of Related Structure

Author:

P. M. JENNER

Year:

1964

Bibliographic source:

Fd Cosmet. Toxicol. Vol. 2, pp. 327-343

Materials and methods

Test guideline

Qualifier:

according to guideline

Guideline:

other: As mentioned below

Principles of method if other than guideline:

Acute oral toxicity of test chemical in rats

GLP compliance:

not specified

Test type:

standard acute method

Limit test:

no

Test material

Test material information

Constituent 1

Reference substance name:

Cinnamaldehyde

EC Number:

203-213-9

EC Name:

Cinnamaldehyde

Cas Number:

104-55-2

Molecular formula:

C9H8O

IUPAC Name:

3-phenylacrylaldehyde

Details on test material:

IUPAC name:3-Phenylpropenol aldehyde
Smiles: c1(ccccc1)/C=C/C=O
InChI:1S/C9H8O/c10-8-4-7-9-5-2-1-3-6-9/h1-8H/b7-4+
Molecular Weight:132.1612
Mol. formula: C9H8O

Test animals

Species:

rat

Strain:

Osborne-Mendel

Sex:

male/female

Details on test animals or test system and environmental conditions:

Fasting period before study: 18 hours

Administration / exposure

Route of administration:

oral: gavage

Vehicle:

unchanged (no vehicle)

Details on oral exposure:

not specified

Doses:

2220 mg/kg bw

No. of animals per sex per dose:

10 (5/sex)

Control animals:

not specified

Details on study design:

- Duration of observation period following administration: 14 days
- Other examinations performed: clinical signs

Statistics:

not specified

Results and discussion

Preliminary study:

not specified

Effect levels

Key result

Sex:

male/female

Dose descriptor:

LD50

Effect level:

2 220 mg/kg bw

Based on:

test mat.

95% CL:

> 1 910 - < 2 600

Remarks on result:

other:

Remarks:

No data

Mortality:

Death observed within 2-3 hours.

Clinical signs:

Clinical signs observed were depression, diarrhea and scrawny appearance

Body weight:

not specified

Gross pathology:

not specified

Other findings:

not specified

Applicant's summary and conclusion

Interpretation of results:

other: Not classified

Conclusions:

The acute oral LD50 value was considered to be 2220 mg/kg bw rats were treated with test chemical via oral route.

Executive summary:

Acute oral toxicity study of test chemical was conducted on 5 male and 5 female rats at the dose concentration of 2220 mg/kg bw. The test chemical was administered via oral intubation route. All animals were maintained under close observation for recording toxic signs and time of death for 14 days. Clinical signs of depression, diarrhea and scrawny appearance followed by death within 2 -3 hrs. Therefore, LD50 value was considered to be 2220 mg/kg bw with 95% confidence level of 1910 -2600 mg/kg bw, when rats were treated with test chemical via oral route.