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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
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EC number: 204-695-3 | CAS number: 124-30-1
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
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Endpoint summary
Administrative data
Description of key information
Key value for chemical safety assessment
Skin sensitisation
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not sensitising)
- Additional information:
There are no valid human data available on sensitization for either the octadecylamines, nor for any other alkylamines considered a chemical category within this chemical safety assessment. Testing in animals with octadecylamines were not performed on animal welfare grounds because read-across from closely related primary alkylamines is possible. Animal data exist on C12 -18 -(even numbered)-alkylamines from a GLP-compliant Magnusson and Kligman maximisation test which demonstrated absence of a significant skin sensitizing potential, as well as from a non-GLP M+K maximisation test with hydrogenated tallow alkylamines which resulted also in an negative outcome. From both studies no significant skin sensitization potential of alkylamines is deducible. These data can be used also in the assessment of tallow alkylamines by applying read-across principles. Additionally, since all alkylamines exhibite strong dermal irritative / corrosive properties, dermal exposure has to be limited anyway.
Migrated from Short description of key information:
No data are available for octadecylamines with regard to skin sensitization. However, data from the closely related primary alkylamines C12-18-(even numberd)-alkylamines and from hydrogenated tallow alkylamines can be used based on read-across principles. In a GLP-compliant skin sensitization study according to OECD TG 406 (Magnusson and Kligman guinea pig-maximization test), 10 female guinea pigs and 5 control animals were treated with C12-18-(even numbered)-alkylamines (Genamin CC 100 D) using cotton seed oil as a vehicle. Based on the results of a pretest, a test concentration of 0.1 % was used for intradermal induction, followed by a 1 % concentration at epidermal induction. Challenge was performed using a 0.5 % substance concentration. After challenge treatment, 2 out of 10 animals showed a grade 1 erythema at the 24 hour reading. As no unequivocal result was obtained after this first challenge, no second challenge tretatment was performed. From the results of this study, no indication of significant skin sensitizing properties exist. Likewise negative results were also obtained with hydrogenated tallow alkylamines.
Respiratory sensitisation
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not sensitising)
- Additional information:
Based on negative skin sensitization data available for primary alkylamines as well as from all other available data, a respiratory sensitization potential of octadecylamines is not to be expected.
Justification for classification or non-classification
Octadecylamines were not tested for skin sensitization for animal welfare reasons because read-across is possible. Maximization tests according to Magnusson and Kligman with two closely related primary alkylamines have not revealed significant skin sensitizing properties.Additionally, octadecylamines exhibite strong dermal irritative properties. Based hereupon, any potential dermal exposure has to be limited anyway.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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