Registration Dossier
Registration Dossier
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EC number: 204-812-8 | CAS number: 126-92-1
Long-term toxicity to fish
Administrative data
Link to relevant study record(s)
Description of key information
42d NOEC (Pimephales promelas; mortality and growth) >= 1.357 mg/L (measured concentration)
Key value for chemical safety assessment
Fresh water fish
Fresh water fish
- Effect concentration:
- 1.357 mg/L
Additional information
Since no reliable chronic fish test is available for C8-isoAS Na (CAS 126-92-1) in accordance to Regulation (EC) No. 1907/2006 Annex XI, 1.5, a read-across to another structurally related category member was conducted. Read-across data from the C12 homologue - C12AS Na (CAS 151-21-3) were used. As the toxicity of alkyl sulfates is dependent on the carbon chain length, it is expected that the toxic effects of C12 homologues are the worst case scenario for the C8 homologue.
A 42-day flow-through study with fathead minnow (Pimephales promelas) examining the toxic effect of CAS 151-21-3 is available (Belanger et al. 1995). Juvenile mortality and juvenile growth were determined in a non-GLP test after exposure to five concentrations up to 1.357 mg/L (measured concentration, equal to 2.1 mg/L of nominal concentration). Since no adverse effects were observed regarding fish survival and body weight, the NOEC was determined as equal to as or greater than 1.357 mg/L (measured concentration). Due to structural and property similarities with the tested category member, it can be concluded that the above results apply also to C8-isoAS Na (CAS 126-92-1).
It seems that both trophic levels - aquatic invertebrates and also fish are similarly sensitive to C8-isoAS Na (CAS 126-92-1). The long-term NOEC values for aquatic invertebrates is 1.4 mg/L and for fish 1.357 mg/L. The more conservative value of 1.357 mg/L was used for the PNEC calculation.
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