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EC number: 201-058-1 | CAS number: 77-78-1
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Guidance on Safe Use
Administrative data
First-aid measures
4.1 General informations
Move victim out of danger zone. Position and transport victim on their side. In case of
respiratory distress, bring into semi-upright, seated position. Remove contaminated
clothing immediatley and dispose off safely. Put victim at rest, cover with a blanket
and keep warm. Do not leave victim unattended. In case of accident or if you feel
unwell, seek medical advice immediately (show safety data sheet if possible).
Symptoms of poisoning may develop several hours following exposure. Victim should
be under medical observation for at least 48 hours after exposure.
Medical advice absolutely requred!
4.2 In case of inhalation
Provide fresh air. In case of breathing difficulties administer oxygen. No mouth-tomouth
or mouth-to-nose resuscitation.Use respiratory bag or oxygen resuscitation
apparatus. When inhaling vapours, first symptoms of poisoning may develop hours
later, so always consult a doctor.
4.3 In case of skin contact
Remove contaminated clothing immediatley and dispose off safely. After contact with
skin, wash immediately with: Water. Subsequently wash again with: Ammonia (3 %).
Symptoms of poisoning may develop several hours following exposure. Victim should
be under medical observation for at least 48 hours after exposure.
4.4 In case of eye contact
In case of contact with eyes, rinse immediately with plenty of flowing water for 10 to
15 minutes holding eyelids apart. Subsequently wash again with: soda solution,
diluted. Subsequently consult an ophthalmologist.
4.5 In case of ingestion
Rinse mouth immediately and drink large quantities of water. Have victim drink large
quantities of water, with active charcoal if possible. Do not induce vomiting.
4.6 Self-protection of the first aider
First aid assistant: Pay attention to self-protection! No mouth-to-mouth or mouth-tonose
resuscitation.Use respiratory bag or oxygen resuscitation apparatus.
4.7 Information to physician
4.7.1 Routes of exposure
The substance can be absorbed into the body by inhalation of its vapour, through the
skin and by ingestion.
4.7.2 Hazards
Effects of short-term exposure:
The substance is corrosive to the eyes, the skin, the
respiratory tract. Corrosive on ingestion. Inhalation of the
vapour may cause lung oedema (see Notes). Ingestion of the
substance may cause oedema of lips, tongue and pharynx.
The substance may cause effects on the liver, kidneys and
central nervous system, resulting in impaired functions.
Exposure above the OEL may result in death. The effects
may be delayed. Medical observation is indicated.
Effects of long-term or repeated
exposure:
Lungs may be affected by repeated or prolonged exposure to
the vapour. This substance is probably carcinogenic to
humans.
Notes:
The onset of symptoms can occur after a relatively
asymptomatic latent period of 6-24 hours. Commercial
dimethyl sulfate may contain trace amounts of sulfuric acid.
Depending on the degree of exposure, periodic medical
examination is suggested. The symptoms of lung oedema
often do not become manifest until a few hours have passed
and they are aggravated by physical effort. Rest and medical
observation are therefore essential. Immediate administration
of an appropriate inhalation therapy by a doctor or a person
authorized by him/her, should be considered. No odour
warning if toxic concentrations are present. Do NOT take
working clothes home. NEVER pour water into this
substance; when dissolving or diluting always add it slowly to
the water.
4.7.3 Symptoms
In case of inhalation:
Burning sensation. Cough. Headache. Shortness of breath.
Sore throat. Symptoms may be delayed
In case of skin contact: MAY BE ABSORBED! Skin burns. Pain. Blisters.
In case of eye contact: Redness. Pain. Blurred vision. Severe deep burns.
In case of ingestion:
Abdominal cramps. Burning sensation. Convulsions.
Diarrhoea. Shock or collapse. Vomiting. (Further see
Inhalation).
4.7.4 Treatment
First Aid, decontamination, treatment of symptoms.
Fire-fighting measures
5.1 Suitable extinguishing media
Foam. Extinguishing powder.
5.2 Extinguishing media which must not be used for safety reasons
Water.
5.3 Special exposure hazards arising from the substance or preparation itself,
combustion products, resulting gases
In case of fire may be liberated:
Carbon monoxide. Carbon dioxide (CO2). Sulphur dioxide (SO2). Sulphur trioxide.
5.4 Special protective equipment for fire-fighters
Wear a self-contained breathing apparatus and chemical protective clothing. In case
of fire: use acidproof devices.
5.5 Additional information
Intervention Actions-General
PUBLIC SAFETY HAZARD - Warn people nearby to stay indoors with doors and
windows closed. Stop any ventilation. Consider evacuation of people in immediate
danger. Keep upwind. Put on protective equipment before entering danger area.
Minimise number of personnel in risk area. Warn people to leave and not to re-enter
basements, sewers or other confined spaces. Keep upwind. Put on protective
equipment before entering danger area.
Intervention Actions-Fire (involving the substance)
Heating of container(s) will cause pressure rise with risk of bursting and subsequent
explosion. Gives off toxic and irritant fumes when heated or burning. May attack
metals and produce hydrogen gas which may form explosive mixture with air. The
vapour may be invisible and is heavier than air. It spreads along the ground and may
enter sewers and basements. Keep container(s) cool with water. Extinguish with
water fog (spray). Do not use water jet to extinguish. Use water spray to knock down
fire fumes if possible. Avoid unnecessary run-off of extinguishing media which may
cause pollution.
ERI-Card
6-57 - HIGHLY TOXIC CORROSIVE LIQUID
Accidental release measures
6.1 Personal precautions (spillage)
Wear personal protection equipment.
6.2 Environmental precautions
Stop leaks if possible. Contain spillage by any means available.
Cover drains. Do not allow to enter into soil/subsoil. Do not empty into drains or the
aquatic environment.
6.3 Methods for cleaning up
Refer to chapter 6.4
6.4 Additional information
Evacuate danger area! Consult an expert! Ventilation. Collect leaking and spilled
liquid in sealable containers as far as possible. Absorb remaining liquid in dry sand or
inert absorbent and remove to safe place. Do NOT wash away into sewer. Personal
protection: complete protective clothing including self-contained breathing apparatus.
Handling and storage
7.1 Handling
7.1.1 Advices on safe handling
Protective measures
Wear personal protection equipment. Refer to chapter 8. Do not eat, drink, smoke or
sneeze at the workplace.
Dangerous areas must be delimited and marked with appropriate warning and safety
signs. In the immediate working surroundings there must be: Emergency spray
installed. provide eye wash and label its location conspicuously. provide sufficient
washing facilities. Fill only into labelled container. Instruction on the hazards and the
protective measures using instruction manual are required with signature.
Working areas must be arranged in such a manner that they can be cleaned at all
times.
7.1.2 Technical measures
Measures to prevent aerosol and dust generation
All work processes must always be designed so that the following is excluded:
Inhalation. Skin contact. Eye contact. Transfer and handle product only in closed
systems.
Measures required to protect the environment
Cover drains. Do not allow to enter into soil/subsoil. Do not empty into drains or the
aquatic environment.
7.1.3 Specific requirements or handling rules
The floor should be leak tight, jointless and not absorbent. Do not transport with/using
compressed air
7.1.4 Precautions against fire and explosion
Usual measures for fire prevention. Inspect the electrical fittings regularly against the
higher risk of corrosion. Welding only under supervision. Work that requires fire or
heat may only be carried out with written permission (e.g. fire permit).
7.2 Storage
7.2.1 Technical measures and storage conditions
Keep in locked storage or only make accessible to specialists or their authorised
assistants. Keep container tightly closed. Keep/Store only in original container. Place
fragile vessels in break-proof outer vessels. Protect against: Humidity. UVradiation/
sunlight.
7.2.2 Hints on storage assembly
Keep away from food, drink and animal feedingstuffs.
7.2.3 Further information on storage conditions
Storage class 6.1 A brennbare giftige Stoffe
Storage temperature 10 °C – 30 °C
Relative air humidity -
Maximum period of storage 2 Jahre / years / Años / ans / anni / jaren
Transport information
Land transport (UN RTDG/ADR/RID)
- UN number:
- 1595
Shipping information
- Proper shipping name and description:
- DIMETHYL SULPHATE
- Chemical name:
- DIMETHYL SULPHATE
- Language:
- English
- Labels:
- T+
SpecialProvisionsopen allclose all
Inland waterway transport (UN RTDG/ADN(R))
- UN number:
- not applicable
Shippingopen allclose all
Remarksopen allclose all
Marine transport (UN RTDG/IMDG)
- UN number:
- not applicable
Shippingopen allclose all
Remarksopen allclose all
Air transport (UN RTDG/ICAO/IATA)
- UN number:
- not applicable
Shippingopen allclose all
Remarksopen allclose all
Additional transport information
Additional information
- Special provisions / remarks / other:
- ADR label: 6.1 + 8
Exposure controls / personal protection
Respiratory protection: Respiratory protection required in case of: exceeding critical value Suitable respiratory protective equipment: Combination filtering device (DIN EN 141). Type of mask: Full-face mask (DIN EN 136). Filtering device: A-P3
Hand protection: Use protective gloves. The glove material must be sufficiently impermeable and resistant to the substance. Check the tightness before wear. Gloves should be well cleaned before being removed, then stored in a well ventilated location. Pay attention to skin care. Textile or leather gloves are completely unsuitable. The following information is valid for aqueous, saturated solutions of the substance. Suitable materials for gloves are (brakthrough time>=8 hours) CR (polychloroprenes, Chloroprene rubber) - CR (0,5 mm); Butyl rubber - Butyl (0,5 mm); The times listed are suggested by measurements taken at 22 degree C and constant contact. Temperatures raised by warmed substances, body heat, etc. and a weakening of the effective layer thickness caused by expansion can lead to a significantly shorter breakthrough time. In case of doubt contact the gloves' manufacturer. A 1.5-times increase / decrease in the layer thickness doubles / halves the breakthrough time. This data only applies to the pure substance. Transferred to mixtures of substances, these figures should only be taken as an aid to orientation.
Eye protection: Suitable eye protection: Tightly sealed safety glasses.
Protective clothing: Suitable protection of the body: Chemical resistant safety shoes. Protective clothing: DIN EN 13034
General health and safety measures: When using do not eat, drink, smoke, sneeze. Wash hands and face before breaks and after work and take a shower if necessary. Draw up skin protection programme. Used working clothes must not be worn outside the working area. Separate storage of work clothes. Immediately remove any contaminated clothing, shoes or stockings. In the immediate working surroundings there must be: Emergency shower installed. Make available sufficient washing facilities. Provide eye shower and label its location conspicuously. Set out skin protection guidelines. Only wear fitting, comfortable and clean protective clothing.
Environmental exposure controls:
See “handling and storage”. No additional measures necessary.
Stability and reactivity
Conditions to avoid: In case of warming: Danger of bursting container. Thermal decomposition can lead to the escape of irritating gases and vapours. Above 83/C explosive vapour/air mixtures may be formed.
Materials to avoid: The vapour is heavier than air. The substance decomposes on heating or on burning producing toxic fumes including sulfur oxides. The solution in water is a medium strong acid. Reacts with water to produce sulfuric acid with evolution of heat. Reacts violently with concentrated aqueous ammonia, bases, acids and strong oxidants with risk of fire and explosion.
Hazardous decomposition products: Sulphur oxides. Carbon monoxide. Carbon dioxide. Methanol. Gas / vapours, irritant and toxic.
Disposal considerations
Collect the waste separately. Waste disposal according to EC-regulations 75/442/EEC and 91/689/EEC in the corresponding versions, covering waste and dangerous waste. Dispose of waste according to applicable local, state, and federal regulations. List of proposed waste codes/waste designations in accordance with EWC. The allocation of waste identity numbers/waste descriptions must be carried out according to the EEC, specific to the industry and process.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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