Benzotriazole

Acute Toxicity: dermal

Administrative data

Endpoint:

acute toxicity: dermal

Type of information:

experimental study

Adequacy of study:

weight of evidence

Reliability:

4 (not assignable)

Rationale for reliability incl. deficiencies:

other: study performed for the endpoint: skin irritation/corrosion, however the results are regarded as piece of evidence for assessment of the endpoint acute toxicity: dermal

Cross-reference

Reason / purpose for cross-reference:

reference to other study

Data source

Reference

Reference Type:

study report

Title:

Unnamed

Year:

1987

Materials and methods

Test guideline

Qualifier:

according to guideline

Guideline:

other: OECD 404

GLP compliance:

not specified

Test type:

other: no acute toxicity test type

Limit test:

no

Test material

Test material information

Constituent 1

Reference substance name:

Benzotriazole

EC Number:

202-394-1

EC Name:

Benzotriazole

Cas Number:

95-14-7

Molecular formula:

C6H5N3

IUPAC Name:

benzotriazole

Constituent 2

Reference substance name:

1,2,3 Benzotriazole

IUPAC Name:

1,2,3 Benzotriazole

Test animals

Species:

rabbit

Strain:

New Zealand White

Sex:

not specified

Details on test animals or test system and environmental conditions:

TEST ANIMALS
- Source:Interfauna UK Ltd
- Weight at study initiation: 3.0 - 3.7 kg
- Housing: standard single animal cages
- Diet: ssniff K 4 ad libitum
- Water: ad libitum
- Acclimation period: two weeks
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 21 +- 2 °C
- Humidity (%): 45 - 65%
- Air changes (per hr): 10
- Photoperiod (hrs dark / hrs light): 12

Administration / exposure

Type of coverage:

semiocclusive

Vehicle:

water

Duration of exposure:

4

Doses:

500 mg of substance

No. of animals per sex per dose:

3

Control animals:

no

Details on study design:

according to guideline OECD 404
TEST SITE
- Area of exposure: 6 cm2
- Type of wrap if used: elastic gluing dressing
REMOVAL OF TEST SUBSTANCE
- Washing (if done): with water
- Time after start of exposure: 4h

Statistics:

none

Results and discussion

Effect levels

Dose descriptor:

discriminating dose

Effect level:

500 other: mg per test site

Mortality:

none

Clinical signs:

other: none

Gross pathology:

not performed

Applicant's summary and conclusion

Interpretation of results:

study cannot be used for classification

Conclusions:

The substance did not induce irritation or signs of toxicity when applied to rabbit skin in vivo. Therefore it is concluded that dermal toxicity is unlikely.

Executive summary:

The substance was tested in a dermal irritation study in rabbits. No mortality or clinical signs incl. signs of irritation were noted. This piece of evidence is taken as supportive for concluding on acute toxicity by dermal route.