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Diss Factsheets
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EC number: 614-074-2 | CAS number: 675106-31-7
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Health surveillance data
Administrative data
- Endpoint:
- health surveillance data
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Study period:
- jan2002 - February 2002
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: a small study carried out using a large proportion of the working population, a deficiency was that the study only considered UK workers - facilites of the study sponsors
Cross-reference
- Reason / purpose for cross-reference:
- reference to same study
Data source
Materials and methods
- Study type:
- medical screening
- Endpoint addressed:
- skin sensitisation
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- Clinical examination of worforce by expert dermatologist
- GLP compliance:
- no
Test material
- Specific details on test material used for the study:
- Occupation exposure to high temperature insulation wools , including polycrystaline wools
Method
- Type of population:
- occupational
- Ethical approval:
- confirmed, but no further information available
- Details on study design:
- Questionaire and full skin examination, clinical screeening.
Results and discussion
Any other information on results incl. tables
Table 2 . Incidental Skin Disease Findings
Incidental findings of skin disease amongst those not complaining of skin problems:
|
Contact dermatitis under leather watch strap |
Viral wart right index finger |
Mild pityriasis |
Pityrosporum folliculitis in scalp body and limbs |
Keratosis pilaris on the arms and the lymphoedema of leg post DVT |
Seborrhoeic dermatitis of the face chest and scalp |
Blue naevus in the scalp/organoid naevus in the scalp |
Multiple naevi |
Plantar wart right heel Two warts right hand skin tag axillae |
Skin tags in axillae and neck |
|
Table 3 –Findings of examination ; Profile of itch when first started
SITE |
Duration |
Findings on examination |
Arms/Face |
Few days |
Nil |
Arms |
Few days |
Nil |
Neck/Arms/Face |
2-3 weeks |
Nil |
Face/Arms |
2-3 Weeks |
Nil |
Forearms |
2 months |
Psoriasis |
Neck/Arms/Legs |
2 weeks |
Acne |
Applicant's summary and conclusion
- Conclusions:
- In the study performed on HTIW workers in UK, no evidence of skin disease, leading to any chronic changes or any skin problems requiring long term treatment, causing long term changes to the skin or fundermentally altering an employees lifestyle where found.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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