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Diss Factsheets
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EC number: 910-757-7 | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1973
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- study well documented, meets generally accepted scientific principles, acceptable for assessment
- Remarks:
- e study was not conducted according to guideline/s and GLP but the report contains sufficient data for interpretation of study results
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 973
- Report date:
- 1973
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 404 (Acute Dermal Irritation / Corrosion)
- GLP compliance:
- no
Test material
- Reference substance name:
- Reaction mass of divinylbenzene and ethylstyrene
- EC Number:
- 910-757-7
- Cas Number:
- N/A
- Molecular formula:
- Divinylbenzene: C10H10 Ethylstyrene: C10H12
- IUPAC Name:
- Reaction mass of divinylbenzene and ethylstyrene
- Details on test material:
- Vapor phase chromatograph (VPC) analysis :
Divinylbenzene 55.7%, Ethylvinylbenzene 40.4%, Diethylbenzene 4.5%, Mass 144-146 1.7%, Naphthalene 0.4%, t-Butyl Catechol 1010 ppm, Polymer 4 ppm
The percentage was determined by measuring the percent area of each component shown in the vapor phase chromatograph and is
considered to be approximately equal to weight percent.
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- not specified
- Details on test animals or test system and environmental conditions:
- No data
Test system
- Type of coverage:
- semiocclusive
- Preparation of test site:
- other: shaved, abraded and unabraded
- Vehicle:
- unchanged (no vehicle)
- Controls:
- no
- Amount / concentration applied:
- 1-2 mL
- Duration of treatment / exposure:
- unabraded, intact skin - 5 days per week for 2 weeks
abraded skin- daily for 3 days
ear - daily 5 days per week for 2 week - Observation period:
- Condition of the skin, at the exposure sites, was assessed and the severity of the reaction recorded daily, 5 days per week, during the esposure period and also at the end of the 3 week study. The animals were weighed at weekly intervals and were frequently observed to detect any changes in behavior and general appearance.
- Number of animals:
- 3
- Details on study design:
- The abdominal skin of three rabbits was shaved free of hair using a straight razor and barber soap. The animals were rested for several days to permit healing of minute razor abrasions. Fresh amounts of the DVB (1-2 mL) were applied each day to an intact and an abraded exposure site on each animal under an absorbent cotton pad held in place by a cloth bandage taped to the animal's trunk. In the case of the intact skin, the test material was applied 5 days per week for 2 weeks which represents a continuous exposure of 14 days. The exposure to abraded skin was repeated daily for 3 days. Daily applications, 5 days per week for 2 weeks, were likewise made to the inner surface of the rabbit ear. Condition of the skin, at the exposure sites, was assessed and the severity of the reaction recorded daily, 5 days per week, during the exposure period and also at the end of the 3-week study. The animals were weighed at weekly intervals and were frequently observed to detect any changes in behaviour and general appearance.
Results and discussion
In vivo
Resultsopen allclose all
- Remarks on result:
- probability of mild irritation
- Irritation parameter:
- erythema score
- Basis:
- animal: all animals
- Time point:
- 24/48/72 h
- Remarks on result:
- other: Slight erythema was observed at the 24-hour observation. Repeated application resulted in slight erythema, very slight necrosis and moderate exfoliation onintact abdominal skin. Moderate necrosis was observed on abraded skin.
- Irritation parameter:
- edema score
- Basis:
- animal: all animals
- Time point:
- 24/48/72 h
- Remarks on result:
- other: Repeated application resulted in slight edema on the intact abdominal skin site.
- Irritant / corrosive response data:
- Twenty-four hours after the first application, little irritation was seen on the rabbits' ears. Slight erythema was observed at all the abdominal sites at the 24-hour observation. Repeated application resulted in slight erythema, slight edema, very slight necrosis and moderate exfoliation on the ear and intact abdominal skin site. The response at the abraded skin sites was greater in that moderate necrosis was observed. No signs of toxicity other than topical effects were observed during the course of the skin irritation study.
Applicant's summary and conclusion
- Interpretation of results:
- Category 2 (irritant) based on GHS criteria
- Conclusions:
- Twenty-four hours after the first application of DVB-55, little irritation was seen. Prolonged skin contact with the test material would likely result in slight redness and slight swelling.
- Executive summary:
The abdominal skin of three rabbits was shaved free of hair using a straight razor and barber soap. The animals were rested for several days to permit healing of minute razor abrasions. Fresh amounts of the DVB (1-2 mL) were applied each day to an intact and an abraded exposure site on each animal under an absorbent cotton pad held in place by a cloth bandage taped to the animal's trunk. In the case of the intact skin, the test material was applied 5 days per week for 2 weeks which represents a continuous exposure of 14 days. The exposure to abraded skin was repeated daily for 3 days. Daily applications, 5 days per week for 2 weeks, were likewise made to the inner surface of the rabbit ear. Condition of the skin, at the exposure sites, was assessed and the severity of the reaction recorded daily, 5 days per week, during the exposure period and also at the end of the 3-week study. The animals were weighed at weekly intervals and were frequently observed to detect any changes in behaviour and general appearance.
Twenty-four hours after the first application, little irritation was seen on the rabbits' ears. Slight erythema was observed at all the abdominal sites at the 24-hour observation. Repeated application resulted in slight erythema, slight edema, very slight necrosis and moderate exfoliation on the ear and intact abdominal skin site. The response at the abraded skin sites was greater in that moderate necrosis was observed. No signs of toxicity other than topical effects were observed during the course of the skin irritation study.
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