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Diss Factsheets
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EC number: 246-278-9 | CAS number: 24468-13-1
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
![](https://echa.europa.eu/o/diss-blank-theme/images/factsheets/A-REACH/factsheet/print_toxicological-information.png)
Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- other information
- Reliability:
- 3 (not reliable)
- Rationale for reliability incl. deficiencies:
- significant methodological deficiencies
- Remarks:
- Study of Industrial Bio-Test Laboratories (IBT).
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Report date:
- 1975
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 402 (Acute Dermal Toxicity)
- Deviations:
- yes
- Remarks:
- 2 animal/sex and dose
- GLP compliance:
- no
- Test type:
- standard acute method
- Limit test:
- no
Test material
- Reference substance name:
- 2-ethylhexyl chloroformate
- EC Number:
- 246-278-9
- EC Name:
- 2-ethylhexyl chloroformate
- Cas Number:
- 24468-13-1
- Molecular formula:
- C9H17ClO2
- IUPAC Name:
- 2-ethylhexyl carbonochloridate
- Details on test material:
- - Name of test material (as cited in study report): 2-ethylhexylchloroformate
- Analytical purity: Purity of the test material was not indicated.
- Other: no further information given
Constituent 1
Constituent 2
Test animals
- Species:
- rabbit
- Strain:
- New Zealand White
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Weight at study initiation: 2.6- 3.0 (males); 2.56- 3.10 (females)
ENVIRONMENTAL CONDITIONS
not reported
Administration / exposure
- Type of coverage:
- occlusive
- Vehicle:
- unchanged (no vehicle)
- Details on dermal exposure:
- TEST SITE
The test site (back) was covered by wrapping the trunk of the animal with an impervious plastic sheeting that was securely taped in place.
- Duration of exposure:
- 14 h
- Doses:
- 600, 900, 1,350, 2,025 or 3,038 mg/kg
- No. of animals per sex per dose:
- 2
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations and weighing: Animals were weighed prior to treatment and at 7 and 14 days (if still alive). Frequency of clinical observation is not reported
- Necropsy of survivors performed: yes
- Other examinations performed: clinical signs, body weight - Statistics:
- none
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 3 038 mg/kg bw
- Mortality:
- One male exposed to 3,038 mg/kg died at 12 days. There were no other deaths.
- Clinical signs:
- other: The test material was severely irritating to the skin. Skin changes at 24 hours were characterized by beet red erythema, severe edema, and focal, superficial and second degree burns in all of the animals. Red, well-defined erythema, superficial escharosi
- Gross pathology:
- Necropsy examination revealed focal hemorrhages in the lungs of one female treated with 900 mg/kg and another treated with 3,038 mg/kg. Red lungs were found in one female treated with 1,350 mg/kg. Emaciation and depletion of body fat stores were observed in the two males treated with 3,038 mg/kg (one died).
Applicant's summary and conclusion
- Conclusions:
- The dermal LD50 is beyond 3,038 mg/kg. 2 -ethylhexylchloroformate is of low systemic toxicity via the dermal route.
- Executive summary:
The study is similar to a OECD 402 dermal toxicity study. Only 2 animals/sex and dose were used. However, the study is sufficient for end point evaluation (valid with restriction). 2 rabbits per sex were exposed to 600, 900, 1,350, 2,025 or 3,038 mg/kg 2 -ethylhexylchloroformate. The test material was severely irritating/corrosive to the skin. One male exposed to 3,038 mg/kg died at 12 days. There were no other deaths. The dermal LD50 is beyond 3,038 mg/kg. Focal hemorrhages in the lung, red lungs respectively point to an inhalative exposure towards 2-ethylhexylchloroformate.
Conclusion: The dermal LD50 is beyond 3,038 mg/kg. 2 -ethylhexylchloroformate is of low systemic toxicity via the dermal route.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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