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EC number: 210-817-6 | CAS number: 623-84-7
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 3 April - 17 April 1986
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: The study was conducted according to test guidelines and in accordance with GLP
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 986
- Report date:
- 1986
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 401 (Acute Oral Toxicity)
- Deviations:
- no
- GLP compliance:
- yes
- Test type:
- standard acute method
- Limit test:
- yes
Test material
- Reference substance name:
- Propane-1,2-diyl diacetate
- EC Number:
- 210-817-6
- EC Name:
- Propane-1,2-diyl diacetate
- Cas Number:
- 623-84-7
- Molecular formula:
- C7H12O4
- IUPAC Name:
- propane-1,2-diyl diacetate
- Details on test material:
- Purity >99.5%
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Wistar
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- Ten young adult rats of the Wistar strain (approximately 6 weeks old) (SPF-quality, randomly bred) were obtained from Iffa-Credo, Brussels, Belgium. Date of arrival at the animal house: March 5, 1986. The quarantine period was 7 days. Another seven days prior to dosing the animals were individually housed in Macrolon cages (acclimation period). The body weights of the males on day 0 ranged from 326 to 360 g and those of the females from 216 to 251 g. The bedding material, purified sawdust (Woody Clean), was received from The Broekman Institute, Someren, The Netherlands. The animals had free access to tap-water and standard laboratory animal diet (RMH-B, pellet diameter 10 mm), which was obtained from Hope Farms, Woerden, The Netherlands. The animal room temperature was maintained at 19-21°C and the relative humidity at 40-70 per cent. The artificial light sequence was 12 hours light, 12 hours dark. Feed was withheld overnight before dosing till approximately 44-43 hours after administration of the test substance.
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- unchanged (no vehicle)
- Details on oral exposure:
- The test substance was dosed as such as a single dose using a stainless steel stomach cannula.
- Doses:
- 5000 mg/kg (dose volume was 4.726 ml/kg body weight).
- No. of animals per sex per dose:
- 5 males and 5 females
- Control animals:
- not specified
- Details on study design:
- The test substance is administered orally by gavage in graduated doses to several groups of rats, one dose being used per group. Subsequently observations of toxic effects and deaths are recorded. Animals which die during the test and those killed at the end of the 14-day observation period are subjected to autopsy.
- Statistics:
- No additional information available.
Results and discussion
- Preliminary study:
- Not applicable.
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 5 000 mg/kg bw
- Based on:
- test mat.
- Mortality:
- None of the rats dosed with 5000 mg/kg died.
- Clinical signs:
- other: No mortalities occurred and no signs of systemic toxicity were observed during the 14-day observation period. There was no evident sex related effect.
- Gross pathology:
- Macroscopic examination of all animals at the end of the study revealed no test substance related gross abnormalities.
- Other findings:
- No additional information available.
Any other information on results incl. tables
No additional information available.
Applicant's summary and conclusion
- Interpretation of results:
- not classified
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- The LD50 value for males and females combined was estimated to exceed 5000 mg/kg body weight. Hence, no classification according to EU criteria is required.
- Executive summary:
One group of Wistar rats, comprising 5 males and 5 females, received a single oral dose of DOWANOL PGDA at 5000 mg/kg body weight.
No mortalities occurred and no signs of systemic toxicity were observed during the 14-day observation period. Weekly group mean body weight gain was normal. There was no evident sex related effect. Macroscopic examination of all animals at the end of the study revealed no test substance related gross.abnormalities.
Since no mortalities occurred, the LD50 value for males and femaIes combined was estimated to exceed 5000 mg/kg body weight.
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