Registration Dossier
Registration Dossier
Data platform availability banner - registered substances factsheets
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 208-993-4 | CAS number: 551-16-6
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Partition coefficient
Administrative data
Link to relevant study record(s)
- Endpoint:
- partition coefficient
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 2009-10-20 to 2010-02-05
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: GLP study conducted to current guidelines.
- Qualifier:
- according to guideline
- Guideline:
- EU Method A.8 (Partition Coefficient)
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Remarks:
- In compliance with UK GLP standards (Schedule 1, Good Laboratory Practice Regulations 1999 (SI 1999/3106 as amended by SI 2004/0994)).
- Type of method:
- shake-flask method to: flask method
- Partition coefficient type:
- octanol-water
- Analytical method:
- high-performance liquid chromatography
- Type:
- log Pow
- Partition coefficient:
- -3.87
- Temp.:
- 22.5 °C
- pH:
- 7
- Type:
- Pow
- Partition coefficient:
- 0
- Temp.:
- 22.5 °C
- pH:
- 7
- Details on results:
- Preliminary estimate:
Approximate solubility in n-octanol: <1.07 x 10-2 g/L
Approximate solubility in water: >1.56 g/L
Approximate Pow: <6.84 x 10-3
Approximate Log10Pow: <-2.17
Definitive test:
Mean Pow: 1.34 x 10 -4
log10Pow: -3.87 Pow
standard deviation : 3.06 x 10 -5 - Conclusions:
- The partition coefficient of the test material has been determined to be 1.34 x 10-4 at 22.5 ± 0.5°C, log10 Pow, -3.87.
Reference
Definitive test results
The mean peak areas obtained for the standard, stock and sample solutions are shown in the following two tables:
Table 3: Organic Phase
Solution |
MeanArea |
Standard 21.4 mg/l |
61.973 |
Standard 21.1 mg/l |
60.446 |
Matrix blank |
none detected |
Sample 1 |
2.954 |
Sample 2 |
3.048 |
Sample 3 |
3.654 |
Sample 4 |
3.326 |
Sample 5 |
4.372 |
Sample 6 |
5.304 |
Table 4: Aqueous Phase
Solution |
MeanArea |
Standard 214 mg/l |
603.407 |
Standard 211 mg/l |
584.841 |
Matrix blank |
none detected |
Sample 1 |
538.535 |
Sample 2 |
541.638 |
Sample 3 |
549.436 |
Sample 4 |
549.135 |
Sample 5 |
552.837 |
Sample 6 |
555.197 |
Stock solution A |
536.324 |
Stock solution B |
534.494 |
Table 5: Total weight (mg) and analysed concentration (mg/L) of the respective phases
Sample Number |
Total Weight (mg) |
Organic Phase |
Aqueous Phase |
|||
Analysed Concentration (mg/L) |
Weight (mg) |
Analysed Concentration (mg/L) |
Weight (mg) |
pH |
||
1 |
201 |
0.205 |
4.31 x 10-2 |
1.93 x 103 |
202 |
6.7 |
2 |
201 |
0.212 |
4.45 x 10-2 |
1.94 x 103 |
203 |
6.4 |
3 |
124 |
0.254 |
6.60 x 10-2 |
1.97 x 103 |
128 |
6.7 |
4 |
124 |
0.231 |
6.01 x 10-2 |
1.96 x 103 |
128 |
6.4 |
5 |
82.4 |
0.304 |
0.104 |
1.98 x 103 |
85.0 |
6.7 |
6 |
82.4 |
0.368 |
0.127 |
1.99 x 103 |
85.4 |
6.5 |
* From analysis of the stock solution † From analysis of the respective phase |
pH of n-octanol saturated water: 7.0
pH of stock solution: 7.0
Temperature: 22.5 ± 0.5°C
Table 6: Determination of the partition coefficient for each sample
Sample Number |
Partition Coefficient |
Log10Pow |
Mean Partition Coefficient |
1 |
1.07 x 10-4 |
-3.97 |
1.08 x 10-4 |
2 |
1.09 x 10-4 |
-3.96 |
|
3 |
1.29 x 10-4 |
-3.89 |
1.23 x 10-4 |
4 |
1.18 x 10-4 |
-3.93 |
|
5 |
1.54 x 10-4 |
-3.81 |
1.70 x 10-4 |
6 |
1.85 x 10-4 |
-3.73 |
Description of key information
The partition coefficient of 6-aminopenicillanic acid was determined using the EU method A8 in the study by Fox and White 2010
Key value for chemical safety assessment
- Log Kow (Log Pow):
- -3.87
- at the temperature of:
- 22.5 °C
Additional information
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.