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EC number: 268-957-9 | CAS number: 68155-37-3 This substance is identified by SDA Substance Name: N-C12-C18 alkyl propylene diamine and SDA Reporting Number: 16-032-00.
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: see 'Remark'
- Remarks:
- The study was performed pre-GLP and not according to standard protocol but comparable with OECD402. The animals were exposed to the test substance was under occlusion and the area of expsoure was 30%. Necropsy is only performed on the that died during the observation period. The substance is corrosive to skin and eyes but in this part of the study nothing is mentioned about skin damage.
Cross-reference
- Reason / purpose for cross-reference:
- reference to same study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 981
- Report date:
- 1981
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 402 (Acute Dermal Toxicity)
- Principles of method if other than guideline:
- The test aniamls were exposed under occlusion and the test ietm covered 30% of the body surface.
- GLP compliance:
- no
- Test type:
- standard acute method
- Limit test:
- yes
Test material
- Reference substance name:
- Amines, N-C12-18-alkyltrimethylenedi-
- EC Number:
- 268-957-9
- EC Name:
- Amines, N-C12-18-alkyltrimethylenedi-
- Cas Number:
- 68155-37-3
- Molecular formula:
- R-NH-(CH2)3-NH2
- IUPAC Name:
- N-C12-18-alkyl-propane-1,3-diamine
- Details on test material:
- Duomeen C (N-coco-1 , 3 diaminopropane) no further data provided
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- New Zealand White
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: H . A . R . E . - Rabbits for Research, Hewitt, N.J., US (H.A.R.E. - Rabbits i s a USDA approved supplier. )
- Age at study initiation: no data
- Weight at study initiation: no data
- Fasting period before study: not applicable
- Housing: individually in wire mesh bottom cages.
- Diet (e.g. ad libitum): ad libitum
- Water (e.g. ad libitum): ad libitum
- Acclimation period: minimum if 5 days
ENVIRONMENTAL CONDITIONS
no data
IN-LIFE DATES:
no data
Administration / exposure
- Type of coverage:
- occlusive
- Vehicle:
- unchanged (no vehicle)
- Details on dermal exposure:
- TEST SITE
- Area of exposure: back and flanks
- % coverage: 30
- Type of wrap if used: The occlusive binder consisted of a layer of plastic wrap, a protective cloth and stockinette binder, all securely held in place with masking tape. The occlusive binder is applied to maintain contact and minimize evaporation of the applied test article .
REMOVAL OF TEST SUBSTANCE
- Washing (if done): The exposure sites were then gently wiped with clean gauze to remove as much nonabsorbed test article as possible.
- Time after start of exposure: After an exposure period of 24 hours.
TEST MATERIAL
- Amount(s) applied (volume or weight with unit): 2g/kg
- Concentration (if solution): -
- Constant volume or concentration used: yes
- Duration of exposure:
- 24h
- Doses:
- 2g/kg
- No. of animals per sex per dose:
- 5
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations and weighing: Body weights were recorded on the initial day of testing and at study termination or day of death.
- Necropsy of survivors performed: no - Statistics:
- E . L . Crow, Biometrika, 43, 423-435 (1956)
Results and discussion
- Preliminary study:
- not peformed
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 2 000 mg/kg bw
- Based on:
- test mat.
- Mortality:
- One animal died during the 14 day observation period on day 13
- Clinical signs:
- other: not reported
- Gross pathology:
- not reported
- Other findings:
- not reported
Applicant's summary and conclusion
- Interpretation of results:
- Category 5 based on GHS criteria
- Remarks:
- Migrated information
- Conclusions:
- One animal died on day 13. The LD50 for duomeen C is therefore > 2000 mg/kg bw
- Executive summary:
The acute dermal toxicity Duomeen C was tested in New Zealand White Rabbits according to a study design similar to OECD 402. The back and flanks of 5 male and 5 female rabbits were clipped, constituting about 30% of the total body surface. Just prior of the application test substance, the skin surface was abraded in 3 of the males and 2 of the females. The animals received 2000 mg/kg undiluted test material, which was left under occlusion for 24 hours. After the 24 hours exposures, the sites were gently wiped with clean gauze to remove non-absorbed material. One animal died during the 15-day observation period on day 13. Consequently, LD50 was determined to be > 2000 mg/kg bw.
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