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EC number: 206-743-9 | CAS number: 372-09-8
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1979-09-17 (application of the test substance)
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Comparable to guideline study; no GLP.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 980
- Report date:
- 1980
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: Federal Register 38 (187): §1500.41, p. 27029, 1973-09-27
- GLP compliance:
- no
- Remarks:
- pre-GLP study
Test material
- Reference substance name:
- Cyanoacetic acid
- EC Number:
- 206-743-9
- EC Name:
- Cyanoacetic acid
- Cas Number:
- 372-09-8
- Molecular formula:
- C3H3NO2
- IUPAC Name:
- cyanoacetic acid
- Details on test material:
- - Name of test material (as cited in study report): Cyanessigsäure (cyanoacetic acid)
- Analytical purity: not given
No further data
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- Vienna White
- Details on test animals or test system and environmental conditions:
- No further data.
TEST ANIMALS
2 male and 4 female Vienna White rabbits
- Source: Gaukler
- Weight at study initiation: mean body weights: 3.30 kg (males); 3.02 kg (females)
- Diet (ad libitum): Ssniff (Intermast)
ENVIRONMENTAL CONDITIONS: no data
No further data.
Test system
- Type of coverage:
- not specified
- Preparation of test site:
- other: shaved (one flank) and abraded (other flank); two test sites at each animal
- Vehicle:
- water
- Controls:
- no
- Amount / concentration applied:
- TEST MATERIAL
- Concentration (if solution): 80% aqueous suspension
Approximately 0.5 g of the test substance was applied to a skin area sized 2.5 cm x 2.5 cm. - Observation period:
- 72 hours
- Number of animals:
- 6
- Details on study design:
- TEST SITE
- Area of exposure: flank (ca. 2.5 cm x 2.5 cm)
SCORING SYSTEM: Draize system according to Draize JH (1959). Dermal Toxicity. In: FDA Appraisal of the Safety of the Chemicals in Foods, Drugs and Cosmetics.
For the estimation of the primary irritation index, the individual scores for erythema and edema at both 24 and 72 h and for both intact and abraded skin were averaged. The sum of the average scores was then divided by 4, resulting in the primary irritation index.
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- primary dermal irritation index (PDII)
- Basis:
- mean
- Remarks:
- (n=6)
- Time point:
- other: 24 - 72 hours
- Score:
- 6.9
- Remarks on result:
- other: Study discontinued after 72 hours because of severe irritation
- Irritation parameter:
- erythema score
- Basis:
- mean
- Remarks:
- (n=6)
- Time point:
- other: 24 - 72 h
- Score:
- 4
- Max. score:
- 4
- Reversibility:
- not reversible
- Remarks on result:
- other: necrosis observed in 6/6 animals
- Irritation parameter:
- edema score
- Basis:
- mean
- Remarks:
- (n=6)
- Time point:
- other: 24 - 72 h
- Score:
- 2.5 - 3.2
- Max. score:
- 4
- Reversibility:
- not reversible
- Irritant / corrosive response data:
- The test substance was a strong irritant; primary irritation index was 6.9 (possible max.: 8.0).
Any other information on results incl. tables
Table: Draize scores and findings for both intact and abraded skin sites
|
Individual scores |
Mean |
Remarks |
||||||
Animal no. |
1 |
2 |
3 |
4 |
5 |
6 |
1 - 6 |
||
Body weight [kg] |
3.31 |
3.22 |
2.80 |
3.28 |
3.05 |
3.00 |
|||
Gender |
male |
female |
female |
male |
female |
female |
|||
Intact skin |
|||||||||
Erythema / Necrosis |
24 h 72 h |
4 / N:s 4 / N:s + |
4/ N:s 4 / N:d + |
4 / N:s 4 / N:d + |
4 / N:s 4 / N:d + |
4 / N:s 4 / N:o + |
4 / N:s 4 / N:d |
4.0 4.0 |
Study was terminated at 72 h due to severe skin findings. |
Edema |
24 h 72 h |
3 2 |
3 3 |
3 3 |
4 2 |
3 3 |
3 2 |
3.2 2.5 |
|
Abraded skin |
|||||||||
Erythema / Necrosis |
24 h 72 h |
4 / N:s 4 / N:s + |
4/ N:s 4 / N:d + |
4 / N:s 4 / N:d + |
4 / N:s 4 / N:d + |
4 / N:s 4 / N:s + |
4 / N:s 4 / N:d |
4.0 4.0 |
Study was terminated at 72 h due to severe skin findings. |
Edema |
24 h 72 h |
3 2 |
3 3 |
3 3 |
4 3 |
3 3 |
3 2 |
3.2 2.7 |
Primary irritation index: 27.5 (sum of mean values) / 4 = 6.9
N:s = necrosis (soft)
N:d = necrosis (deep), reaching the muscle layer
N:o = necrosis (open)
+: finding confirmed by macroscopic pathology
Applicant's summary and conclusion
- Interpretation of results:
- Category 1B (corrosive) based on GHS criteria
- Remarks:
- Migrated information: considering the results of this study and also those of the BASF screening test, see entry BASF 78/833_screening.Skin irritation/corrosion in this section
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