Registration Dossier
Registration Dossier
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EC number: 230-743-8 | CAS number: 7299-99-2
Endpoint summary
Administrative data
Description of key information
Additional information
Regarding aquatic bioaccumulation, the substance is thought to have limited bioaccumulation potential, at least not enough to be classified as a (very) bioaccumulative substance. Using the available QSAR models (e.g.TGD BCF fish, BCFBAF v3.00 in EPISuite 4.0), the predicted BCF values are below 32.1 L/kg wet-wt () (See Chemical Safety Report, section 8). The predicted values are far below the threshold value of 5000 L/kg for a very bioaccumulative substance, and well below the value of 2000 L/kg for bioaccumulative substances.Therefore, further testing is not considered necessary.
This is further endorsed by the potential for bioaccumulation to diminish as log Kow increases above a value of 6. Substances with log Kow between 3 and 6 are considered highly accumulating; however no substantial bioconcentration is assumed for compounds having log Kow with values less than 3 or greater than 6. This correlation has been validated by comparison of published BCF values with the respective calculated log Kow values; the results generally revealing increasing BCF values with increasing log Pow. For compounds having log Kow greater than 6, a gradual decrease of the BCF is observed. It has been hypothesised within the published literature that a high log Kow is more an effect of solubility than a tendency of the substance to be lipophilic.
Suitable references for this are listed in:
Nagel, R. ; Loskill, R.: Bioaccumulation in Aquatic Systems - Contributions to the Assessment.Proceedingsof an International Workshop Weinheim: VCH Verlagsgesellschaft, Fraunhofer IUCT (now IME), 1991 ISBN: 3-527-28395-1 pp.43-66 : Abb.,Tab.
Gary M Rand: Fundamentals of Aquatic Toxicology, Effects, Environmental Fate and Risk Assessment
Second Edition; Taylor & Francis, 1995, ISBN:1-56032-091-5 pp.626-629
Guidance for Meeting the SIDS Requirements: Chemical Right-to-Know Initiative,
http://www.epa.gov/opptintr/chemrtk/sidsappb.htm, Section 2.5
The Revised GESAMP Hazard Evaluation Procedure for Chemical Substances Carried by Ships, IMO/FAO/UNESCO±IOC/WMO/WHO/IAEA/UN/UNEP, Joint Group of Experts on the Scientific Aspects of Marine Environmental Protection (GESAMP), The Revised GESAMP hazard evaluation procedure; Pow ca. >7.0 equates to BCF not measurable
As the substance is not manufactured in Europe and at formulation or use waste is not disposed of via a waste water treatment plant, but incinerated, the environment is not expected to be exposed.Therefore, further testing is not considered necessary.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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