Registration Dossier

Administrative data

Link to relevant study record(s)

Description of key information

Key value for chemical safety assessment

Additional information

DOW (1983) reported the fate of the the test substance in male rats following inhalation exposure. The following was stated: BO is extensively metabolised and rapidly eliminated following either inhalation exposure or gavage in F344 male rats. 100, 400, 2000 ppm BO caused dose-related depletion of non-protein sulfhydryl groups in liver and kidney tissue. Conjugation of BO with GSH is an important detoxification mechanism in rodents. On the other hand, depletion of GSH is also correlated with enhanced oxidative stress and cell proliferation. Steady-state uptake rates of BO were determined to be 0.0433 mg/kg/min at 50 ppm and 0.720 mg/kg/min at 1000 ppm. These rates correspond to an estimated uptake of 15.6 and 252 mg/kg during a six hour exposure. It appears that physical and biological processes involved in absorption, metabolism and elimination of BO are essentially linear throughout the exposure range of 50 - 1000 ppm.