Registration Dossier
Registration Dossier
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EC number: 236-921-1 | CAS number: 13548-38-4
Endpoint summary
Administrative data
Key value for chemical safety assessment
Additional information
According to Chapter R.7a: Endpoint specific guidance, table R.7.7-5, row 9, no further tests are required since available data ( results from in vitro gene mutation in bacteria and cytogenicity study in vitro and in vivo) is sufficient to conclude that test article is non-mutagenic.
In bacterial tests, chromic nitrate compounds have shown mainly negative results. De Flora et al. (1990) summarized the results of 11 studies on chromium(III) nitrate. The assays included various types of tests with Escherichia coli, Salmonella typhimurium, and Bacillus subtilis with and without metabolic activation systems. With few exceptions contaminated with Cr (VI), these studies showed negative results. Positive doses were generally very high. One Ames test study on gene mutation by chromic nitrate in S. typhimurium was also negative (Venier et al, 1982)
In old studies in cultured mammalian cells, chromic nitrate gave negative effect when tested for chromosomal aberrations with human lymphocytes (Nakamuro et al., 1978). In addition, Venier et al. (1982) observed that chromic nitrate cannot increase in SCEs and chromosomal aberration used as parameters of clastogenicity in Chinese hamster ovary cells when the incubation time was 30 h to cover two division cycles, unless contaminated by Cr (VI) compounds. The results summarized in another report published by Bianchi V et al. supported the conclusion as discussed above.
In the report published by De Flora et al. (1990), summarized that chromic nitrate produced negative response in in vivo micronuclei assay conducted with mouse.
Short description of key information:
Based on the available data, chromic nitrate showed mainly negative results in bacterial assay and cultured mammalian cells, with few exception contaminated with Cr (VI).
Endpoint Conclusion: No adverse effect observed (negative)
Justification for classification or non-classification
Based on the results as discussed, chromium trinitrate showed negative mutagenic results, thus, it does not require classification according to CLP (Regulation EC No. 1272/2008) or DSD (Directive 67/548/EEC).
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