Registration Dossier
Registration Dossier
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EC number: 254-996-9 | CAS number: 40601-76-1
Bioaccumulation: aquatic / sediment
Administrative data
Link to relevant study record(s)
Description of key information
1,3,5-tris[[4-tert-butyl-3-hydroxy-2,6-xylyl]methyl]-1,3,5-triazine-2,4,6(1H,3H,5H)-trione has an estimated log Kow of 15.28 and predicted BCF values well below the 2000 threshold. It is generally accepted that substances with such a high log Kow are very unlikely to have the ability to cross cell membranes and therefore are very unlikely to accumulate in aquatic organisms (Guidance on IR&CSA, Chapter R.11). This is further supported by the lack of systemic toxicity in toxicity studies with mammals.
Based on the information available and in accordance with the recommendations of Chapter R.7c of the Guidance on IR&CSA on applying a Weight-of-Evidence approach, it is concluded that the substance is not bioaccumulative or very bioaccumulative in aquatic organisms. The value of the only reliable QSAR prediction is used for the assessment, i.e. 31.7 L/kg ww.
Key value for chemical safety assessment
- BCF (aquatic species):
- 37.1 L/kg ww
Additional information
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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