Registration Dossier
Registration Dossier
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EC number: 242-272-5 | CAS number: 18395-30-7
Endpoint summary
Administrative data
Description of key information
In a skin irritation study conducted according to OECD 404 and to GLP (Hüls Prüfinstitut für Toxikologie, 1993b), Dynasylan IBTMO (trimethoxy(2-methylpropyl)silane) was irritating to the skin of small white Russian rabbits. There were no signs of systemic toxicity.
In an eye irritation study conducted to a protocol similar to OECD 405, and to GLP (Hüls Prüfinstitut für Toxikologie, 1993c), Dynasylan IBTMO (isobutyltrimethoxysilan) was not irritating to the eyes of small white Russian rabbits. There were some minor signs of irritation involving the conjunctivae, that had reversed by 72 hours in two of the animals and by day 6 in one animal.
Key value for chemical safety assessment
Skin irritation / corrosion
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed (irritating)
Eye irritation
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not irritating)
Respiratory irritation
Endpoint conclusion
- Endpoint conclusion:
- no study available
Additional information
The key studies are the only data available for skin and eye irritation.
Justification for selection of skin irritation / corrosion endpoint:
The selected study is the only skin irritation study available for the registered substance. It was conducted in accordance with an appropriate OECD test guideline and in compliance with GLP.
Justification for selection of eye irritation endpoint:
The selected study is the only eye irritation study available for the registered substance. It was conducted in accordance with an appropriate OECD test guideline and in compliance with GLP.
Effects on skin irritation/corrosion: irritating
Justification for classification or non-classification
Based on the available in vivo data, trimethoxy(2 -methylpropyl)silane is classified as a 'Cat 2: Skin irritant' with the hazard statement 'H315: Causes skin irritation' according to Regulation (EC) No 1272/2008. There is no classification for eye irritation, based on in vivo data.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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