Registration Dossier
Registration Dossier
Data platform availability banner - registered substances factsheets
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 421-820-9 | CAS number: 192268-65-8 CD 28-0132; IRGALUBE 232
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Short-term toxicity to fish
Administrative data
Link to relevant study record(s)
Description of key information
The substance is not acutely toxic to fish in the range of solubility.
Key value for chemical safety assessment
Additional information
Whole substance (CAS 192268 -65 -8)
A study conducted according to OECD guideline 203 with the uvcb substance is available (RCC Umweltchemie AG, 1997). A water accommodated fraction was prepared for the investigation. Zebra fish were used as test organisms and the LC50 after 96 hours of semi-static exposure was determined to be > saturation concentration (undiluted filtrate of a nominal loading rate of 100 mg/L). No effects were observed up to highest tested concentration and saturation concentration, respectively.
Structure A (CAS 597 -82 -0)
Two studies on the acute toxicity to fish are available.
In the most recent study (RCC 2002) which was performed according to GLP, zebra-fish (Brachydanio rerio) were exposed for 96-h to the test item at concentrations of 0 (control, solvent control) and saturation concentration (undiluted filtrate with a nominal loading rate of 100 mg/L) under static conditions. The 96-h LC50 was higher than the saturation concentration. The NOECs, based on mortality and sublethal effects, were ≥ the saturation concentration, respectively. Sublethal effects were not observed.
In addition, the 96-h acute toxicity to zebra-fish (Brachydanio rerio) was determined in a supportive non-GLP study (Ciba-Geigy, 1988). In this study test organisms were exposed to test item at nominal concentrations of 0 (control, solvent control), 1.8, 3.2, 5.8, 10, 18, 32, 58 and 100 mg/L for 96-h under static conditions. The 96-h LC50 was 83 mg/L. The LC0 was 18 mg/L. However, high vehicle concentration was used and undissolved test item was observed in concentrations above 18mg/L and observed adverse effect could relate to this fact.
Thus, it can be concluded that the test substance is not acutely toxic to fish at the range of solubility.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.