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EC number: 232-218-9 | CAS number: 7790-69-4
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: inhalation
Administrative data
- Endpoint:
- acute toxicity: inhalation
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1999-12-07 to 2000-02-14
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 999
- Report date:
- 2000
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 403 (Acute Inhalation Toxicity)
- Version / remarks:
- May 12th 1981
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- EU Method B.2 (Acute Toxicity (Inhalation))
- Version / remarks:
- December 29th 1992
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- EPA OPPTS 870.1300 (Acute inhalation toxicity)
- Version / remarks:
- August 1998
- Deviations:
- no
- GLP compliance:
- yes
- Test type:
- standard acute method
- Limit test:
- yes
Test material
- Reference substance name:
- Lithium nitrate
- EC Number:
- 232-218-9
- EC Name:
- Lithium nitrate
- Cas Number:
- 7790-69-4
- Molecular formula:
- HNO3.Li
- IUPAC Name:
- lithium nitrate
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Charles River Laboratories
- Age at study initiation: young adults
- Weight at study initiation: 247-268 g
- Fasting period before study: no
- Housing: individually housed in stainless steel, suspended cages
- Diet (e.g. ad libitum): Purina Rodent Chow 5001 (pellets), ad libitum
- Water (e.g. ad libitum): tap water, ad libitum
- Acclimation period: 5 days
ENVIRONMENTAL CONDITIONS
- Temperature (°F): 67-68
- Humidity (%): 52-61
- Photoperiod (hrs dark / hrs light): 12/12
Administration / exposure
- Route of administration:
- inhalation: aerosol
- Type of inhalation exposure:
- nose only
- Vehicle:
- clean air
- Details on inhalation exposure:
- GENERATION OF TEST ATMOSPHERE / CHAMBER DESCRIPTION
- Exposure apparatus: a dynamically-operated, nose-only inhalation exposure chamber with 11 litres volume
- Method of holding animals in test chamber: housed in polycarbonate nose-only tubes during the exposure
- Method of particle size determination: The aerodynamic particle size distribution was determined by gravimetric analysis of the amount of test material collected on the impactor stages.
- Temperature, humidity, pressure in air chamber: Chamber, room air temperature and relative humidity were monitored continuously during the exposure with FMC wet/dry bulb hygrometers. Measurements were recorded at 30-minute intervals. The mean temperature and relative humidity in the chamber were 69 °F and 74 %, respectively. The mean temperature and relative humidity in the chamber room were 64 °F and 50 %, respectively.
TEST ATMOSPHERE
- Brief description of analytical method used: Chamber air samples were taken on German® Type A/E 37 mm glass fiber filters held in cassettes at approximately 40-minute intervals during the exposure to determine the airborne concentration of test material. The concentration was calculated by dividing the filter weight gain by the sample volume. The filters were then desiccated overnight and reweighed for determination of dry concentration. The dry concentration was then divided by the fraction of solids (0.32) to yield the formulation concentration.
- Samples taken from breathing zone: Yes, the samples were taken from the center of the chamber directly above the animal tube portals.
TEST ATMOSPHERE
- Particle size distribution: Chamber air samples were taken twice during the exposure to determine the aerodynamic particle size distribution of airborne test material. The samples were drawn through a Sierra® Model 218 cascade impactor at 2.82 liters per minute. The filters were then desiccated overnight and reweighed for determination of dry filter weight.
- MMAD (Mass median aerodynamic diameter) / GSD (Geometric st. dev.): The mass median aerodynamic diameter (MMAD), geometric standard deviation (GSD) and the percent of aerosol less than or equal to 1,10, and 15 microns in size were determined by logarithmic-probability plotting. - Analytical verification of test atmosphere concentrations:
- yes
- Duration of exposure:
- 4 h
- Concentrations:
- formulation concentration: 5.93 mg/L
- No. of animals per sex per dose:
- 5 animals/sex/dose
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations and weighing: observations at fifteen-minute intervals during the first hour of exposure, hourly for the remainder of the exposure, upon removal from the chamber, at one hour post-exposure and daily thereafter for fourteen days
- Necropsy of survivors performed: yes
- body weight: once a week - Statistics:
- Particle size distributions were determined by log-probability plotting of the data and subsequent determination of the mass median aerodynamic diameter, geometric standard deviation and other particle size parameters from the data plots. The LC50 and 95 % confidence limits were determined by a suitable logit or probit analysis.
Results and discussion
Effect levels
- Key result
- Sex:
- male/female
- Dose descriptor:
- LC50
- Effect level:
- > 5.93 mg/L air
- Based on:
- test mat.
- Exp. duration:
- 4 h
- Mortality:
- There were no deaths during the study.
- Clinical signs:
- other: Treatment-related clinical signs noted during the study included dyspnea and lacrimation. All animals were normal on study day 1 and remained normal through study termination. Another sign noted that was attributed to animal exposure tube confinement was
- Body weight:
- At termination, all animals exhibited increases in body weight over their day 0 values.
- Gross pathology:
- There were no gross internal lesions observed in any animal at necropsy.
- Other findings:
- The results of the particle size distribution indicated the test material was respirable in size to the rat.
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- Under the conditions of this study, the four-hour LC50 for lithium nitrate solution was greater than 5.93 mg/L.
- Executive summary:
A group of five male and five female Sprague-Dawley rats was exposed to a respirable aerosol of lithium nitrate solution (30 %). Animals were exposed for 4 hours at a mean, formulation concentration of 5.93 mg/L in a dynamically-operated, nose-only inhalation exposure chamber. Gravimetric airborne test material samples were taken frequently during the exposure. Particle size samples were taken twice during the exposure. Observations for toxicity and mortality were performed frequently during the exposure, upon removal of the rats from the chamber, at one hour post-exposure and daily thereafter for 14 days. Individual body weights were recorded immediately prior to exposure on day 0 and on days 7 and 14. On day 14, all animals were sacrificed and gross necropsy examinations were performed.
All animals survived to study termination. Treatment-related clinical signs noted during the study included dyspnea and lacrimation. All animals were normal from day 1 through study termination. All animals gained weight during the study. There were no gross internal lesions observed in any animal at necropsy.
Under the conditions of this study, the four-hour LC50 for lithium nitrate solution is greater than 5.93 mg/L. (FMC, 1999/2000)
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