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Diss Factsheets
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EC number: 200-652-8 | CAS number: 67-43-6
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
Multiple skin and eye irritation studies using the DTPA acid and the pentasodium and potassium salts
Key value for chemical safety assessment
Skin irritation / corrosion
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not irritating)
Eye irritation
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed (irritating)
Respiratory irritation
Endpoint conclusion
- Endpoint conclusion:
- no study available
Additional information
Skin Irritation:
The various studies available for DTPA acid, pentapotassium salt and pentasodium salt indicate that DTPA is not irritating to the skin.
Whilst DTPA acid, and the pentasodium and potassium salts would not be irritating to the skin, the residual sodium hydroxide present in some formulations of pentasodium DTPA can result in the solution being irritant or even corrosive, however this is due entirely to the presence of the sodium hydroxide.
Eye Irritation:
DTPA acid appears to be irritating in a minimally reported study. There was no assessment of the irritancy according to the Draize criteria, and the assessment of irritancy was therefore entirely qualitative. Studies performed using the sodium salt generally indicate a lack of irritancy to eyes whereas a study using the potassium salt showed slight eye irritation while a 40% solution of the potassium salt did not. These salts are placed on the market as solutions of approximately 40% chelating agent in water. Some of these solutions contain residual hydroxide left over by the manufacturing process. As with the skin irritation, this residual hydroxide can significantly increase the irritation potential. However if one considers the DTPA salts on their own, then the data indicate that there is a lack of eye irritation potential according to current guidelines with regard to the sodium salt and only slight irritation in case of the potassium salt. Considering that DTPA-H5 is an acid, and considering the reported reactions (extensive conjunctivitis, and moderate corneal damage) it is noted that this substance would likely be considered as an irritant to the eyes if a new guideline study were performed.
Respiratory irritation:
No data are available relating to respiratory irritation.
Effects on eye irritation: irritating
Justification for classification or non-classification
Skin irritation / corrosion: not irritating
Eye irritation: Category 2 (GHS)
DTPA-H5 does not meet the requirements for classification for skin irritation, but should be classified for eye irritation GHS Cat. 2 as described in the Guidance on the Application of the CLP criteria, Version 4.0 (2013).
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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