Registration Dossier
Registration Dossier
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EC number: 218-787-6 | CAS number: 2235-00-9
Adsorption / desorption
Administrative data
Link to relevant study record(s)
Description of key information
Adsorption to solid soil phase is not expected at environmentally relevant conditions.
Key value for chemical safety assessment
- Koc at 20 °C:
- 46.88
Additional information
QSAR-disclaimer
In Article 13 of Regulation (EC) No 1907/2006, it is laid down that information on intrinsic properties of substances may be generated by means other than tests, provided that the conditions set out in Annex XI (of the same Regulation) are met.
According to Annex XI of Regulation (EC) No 1907/2006 (Q)SAR results can be used if (1) the scientific validity of the (Q)SAR model has been established, (2) the substance falls within the applicability domain of the (Q)SAR model, (3) the results are adequate for the purpose of classification and labeling and/or risk assessment and (4) adequate and reliable documentation of the applied method is provided.
For the assessment of the test substance (Q)SAR results were used for the estimation of the adsorption potential. The criteria listed in Annex XI of Regulation (EC) No 1907/2006 are considered to be adequately fulfilled and therefore the endpoint(s) sufficiently covered and suitable for risk assessment.
Therefore, further experimental studies on the adsorption potential are not provided.
Assessment
To assess the adsorption potential of CAS 2235-00-9 no experimental data exist. Therefore, the Koc value was estimated using QSAR models. According to the MCI method of the KOCWIN v2.00 module of EPI Suite v4.11, the substance has a Koc of 47 L/kg and a log Koc of 1.7 (BASF SE, 2021). The MCI module is more reliable than the log Kow method of KOCWIN v2.00, which estimates the Koc based on the n-octanol/water partition coefficient (log Kow of of 1.2 (see IUCLID Ch. 4.7). The latter method resulted in a Koc of 34.8 L/kg and a log Koc of 1.5. The substance was within the applicability domain of the models. At environmentally relevant conditions, the substance does not dissociate in the environemntal relevant pH-range (See IUCLID Ch. 4.21).
It can be concluded, that adsorption to solid soil phase is not expected at environmentally relevant conditions.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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