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The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
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EC number: 203-646-3 | CAS number: 109-09-1
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Toxicity to aquatic algae and cyanobacteria
Administrative data
- Endpoint:
- toxicity to aquatic algae and cyanobacteria
- Type of information:
- migrated information: read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- weight of evidence
- Study period:
- 1991
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Guideline study without detailed documentation.
Data source
Reference
- Reference Type:
- secondary source
- Title:
- Unnamed
- Year:
- 1 991
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 201 (Alga, Growth Inhibition Test)
- Deviations:
- not specified
- GLP compliance:
- yes
Test material
- Reference substance name:
- 3-methylpyridine
- EC Number:
- 203-636-9
- EC Name:
- 3-methylpyridine
- Cas Number:
- 108-99-6
- IUPAC Name:
- 3-methylpyridine
- Details on test material:
- - Name of test material (as cited in study report): 3-Methylpyridine
Constituent 1
- Specific details on test material used for the study:
- Details on properties of test surrogate or analogue material (migrated information):
- Melting point: -18.1ºC
- Boiling point: 143-144ºC
- Vapour pressure: 6.05 mm Hg at 25ºC
- Water solubility (under test conditions):
- Henry's law constant: 7.73 x 10E-6 atm-cu m/mol at 25ºC
- log Pow: 1.20
- pKa: 5.63 at 25ºC
Reference: HSDB® is provided quarterly by US National Library of Medicine and was last updated December 18, 2009
Sampling and analysis
- Analytical monitoring:
- no
Test solutions
- Vehicle:
- no
- Details on test solutions:
- The growth medium used in the test was prepared according to the OECD guideline. The medium was filter-sterilized with a 0.45 µm membrane filter.
Test solutions were prepared by adding an aliquot from each of five stock solutions (1, 3.2, 10, 32 and 100 g test substance/L) to the appropriate test flasks.
Test organisms
- Test organisms (species):
- Raphidocelis subcapitata (previous names: Pseudokirchneriella subcapitata, Selenastrum capricornutum)
- Details on test organisms:
- - Strain: CCAP 278-4
- Source (laboratory, culture collection): CCAP, UK
- Method of cultivation: The algae were cultured at the testing facility for several weeks in Boltz Basal Medium (BBM).
Study design
- Test type:
- static
- Water media type:
- freshwater
- Limit test:
- no
- Total exposure duration:
- 72 h
Test conditions
- Test temperature:
- 25 ± 1ºC
- pH:
- Not reported in summary.
- Nominal and measured concentrations:
- Nominal concentrations: 0, 10, 32, 100, 320 and 1000 mg/L
- Details on test conditions:
- Test vessels were all-glass 100-mL Erlenmeyer flasks containing 50 mL of test solution. Triplicate flasks were used at each test concentration. Test solutions were prepared by adding an aliquot from each of five stock solutions (1, 3.2, 10, 32 and 100 g test substance/L) to the appropriate test flasks. Flasks were inoculated with algal cells to achieve an initial cell density of 10E4 cells/mL. Flasks were incubated n an environmental cabinet under continuous illumination at a temperature of 25 ± 1ºC. Flasks were continuously shaken during the experiment. Cell counts were made after 3 days of incubation using a Neubauer counting chamber. The average specific growth rate was calculated for each flask and the average growth rate for each treatment was compared to the control group. The pH of the test solutions was measured in each flask at the beginning and end of the test.
- Reference substance (positive control):
- not specified
Results and discussion
Effect concentrations
- Duration:
- 72 h
- Dose descriptor:
- EC50
- Effect conc.:
- 320 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- growth rate
- Reported statistics and error estimates:
- No statistics applied to data.
Applicant's summary and conclusion
- Validity criteria fulfilled:
- not specified
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.