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EC number: 221-499-3 | CAS number: 3121-61-7
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Eye irritation
Administrative data
- Endpoint:
- eye irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Basic data given. The study period was terminated at day 7, therefore only limited information on reversibility.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 980
- Report date:
- 1980
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- other: EPA 40 CFR 163.81.4
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 405 (Acute Eye Irritation / Corrosion)
- Deviations:
- yes
- Remarks:
- the study was terminated at day 7; data on reversibilty is in some of the animals not available.
- GLP compliance:
- no
Test material
- Reference substance name:
- 2-methoxyethyl acrylate
- EC Number:
- 221-499-3
- EC Name:
- 2-methoxyethyl acrylate
- Cas Number:
- 3121-61-7
- Molecular formula:
- C6H10O3
- IUPAC Name:
- 2-methoxyethyl acrylate
- Details on test material:
- - Name of test material (as cited in study report): Sipomer MCA
- Physical state: clear liquid
- Analytical purity: > 99%
- Lot No.: E169H8
Constituent 1
Test animals / tissue source
- Species:
- rabbit
- Strain:
- other: New Zealand Albino
- Details on test animals or tissues and environmental conditions:
- TEST ANIMALS
- Source: Skippack Farms, Sippack, PA, USA
- Housing: During the test period, the rabbits were housed in individual stainless steel wire bottomed cages.
- Diet: Fisher Rabbit Pellets; ad libitum
- Water: ad libitum
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 20.0-22.2
- Photoperiod (hrs dark / hrs light): 12/12
Test system
- Vehicle:
- unchanged (no vehicle)
- Controls:
- other: the untreated eye served as control
- Amount / concentration applied:
- TEST MATERIAL
- Amount(s) applied: 0.1 mL - Duration of treatment / exposure:
- 6 animals: single application without washing
3 animals: 30 s - Observation period (in vivo):
- 7 days
Reading time points: 24, 48 and 72 h as well as 4 and 7 days - Number of animals or in vitro replicates:
- 6 animals: unwashed eyes after instillation
3 animals: washed eyes after instillation - Details on study design:
- REMOVAL OF TEST SUBSTANCE
- Washing (if done): 20 mL lukewarm water
- Time after start of exposure: 30 s after instillation
SCORING SYSTEM: Draize scoring system
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- conjunctivae score
- Basis:
- animal #1
- Remarks:
- (unwashed eyes)
- Time point:
- 24/48/72 h
- Score:
- 2
- Max. score:
- 3
- Reversibility:
- not fully reversible within: 7 days
- Irritation parameter:
- conjunctivae score
- Basis:
- animal #2
- Remarks:
- (unwashed eyes)
- Time point:
- 24/48/72 h
- Score:
- 2.3
- Max. score:
- 3
- Reversibility:
- fully reversible within: 7 days
- Irritation parameter:
- conjunctivae score
- Basis:
- animal #3
- Remarks:
- (unwashed eyes)
- Time point:
- 24/48/72 h
- Score:
- 2.3
- Max. score:
- 3
- Reversibility:
- not fully reversible within: 7 days
- Irritation parameter:
- conjunctivae score
- Basis:
- animal: #4 and #5 (unwashed eyes)
- Time point:
- 24/48/72 h
- Score:
- 2
- Max. score:
- 3
- Reversibility:
- fully reversible within: 7 days
- Irritation parameter:
- conjunctivae score
- Basis:
- animal #6
- Remarks:
- (unwashed eyes)
- Time point:
- 24/48/72 h
- Score:
- 3
- Max. score:
- 3
- Reversibility:
- not fully reversible within: 7 days
- Irritation parameter:
- chemosis score
- Basis:
- animal #1
- Remarks:
- (unwashed eyes)
- Time point:
- 24/48/72 h
- Score:
- 3.3
- Max. score:
- 4
- Reversibility:
- not fully reversible within: 7 days
- Irritation parameter:
- chemosis score
- Basis:
- animal: #2, #3, #4, #5 and #6 (unwashed eyes)
- Time point:
- 24/48/72 h
- Score:
- 4
- Max. score:
- 4
- Reversibility:
- not fully reversible within: 7 days
- Irritation parameter:
- iris score
- Basis:
- animal: #1, #2, #3 and #4 (unwashed eyes)
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 2
- Irritation parameter:
- iris score
- Basis:
- animal #5
- Remarks:
- (unwashed eyes)
- Time point:
- 24/48/72 h
- Score:
- 0.3
- Max. score:
- 2
- Reversibility:
- fully reversible within: 48 hours
- Irritation parameter:
- iris score
- Basis:
- animal #6
- Remarks:
- (unwashed eyes)
- Time point:
- 24/48/72 h
- Score:
- 1
- Max. score:
- 2
- Reversibility:
- fully reversible within: 7 days
- Irritation parameter:
- cornea opacity score
- Basis:
- animal #1
- Remarks:
- (unwashed eyes)
- Time point:
- 24/48/72 h
- Score:
- 1
- Max. score:
- 4
- Reversibility:
- not fully reversible within: 7 days
- Irritation parameter:
- cornea opacity score
- Basis:
- animal #2
- Remarks:
- (unwashed eyes)
- Time point:
- 24/48/72 h
- Score:
- 1.3
- Max. score:
- 4
- Reversibility:
- not fully reversible within: 7 days
- Irritation parameter:
- cornea opacity score
- Basis:
- animal: #3, #4, #5 and #6 (unwashed eyes)
- Remarks:
- (unwashed eyes)
- Time point:
- 24/48/72 h
- Score:
- 2
- Max. score:
- 4
- Reversibility:
- not fully reversible within: 7 days
- Irritant / corrosive response data:
- The test substance was found to be an eye irritant in the unwashed eyes of 6 rabbits. All animals showed effects on the cornea (scores 1-2) and conjunctivae (redness: score 1-3; chemosis: score 1-4). In 3 of 6 animals conjunctival redness was fully reversible within 7 days. Whereas conjunctival oedemas were persistent in all animals at any time during the test. Corneal opacity was only reversed in 1 of 6 animals within the observation period of 7 days. Effects on iris (scores of 1) were observed in 2 of 6 animals and were fully reversible within 7 days. As none of the animals was completely free from signs of eye irritation within the observation period of 7 days and it is unknown whether these effects on the cornea and conjunctiva are transient or persistent within an observation period of 21 days, the test substance needs to be classified into Category 1.
The severity and duration of the irritation to the eyes was reduced in the washed eyes of 3 tested animals. However, in one animal, effects on conjunctival redness and chemosis were not fully reversible within 7 days.
Any other information on results incl. tables
Table 1. Results of the unwashed eyes
Rabbit #
|
Time [h]
|
conjunctivae
|
iris
|
cornea
|
|
conjunctivae
|
iris
|
cornea
|
||||
redness |
swelling |
redness |
swelling |
|||||||||
1
|
|
|
|
|
|
|
||||||
24 |
2 |
3 |
0 |
1 |
||||||||
48 |
2 |
4 |
0 |
1 |
||||||||
72 |
2 |
3 |
0 |
1 |
||||||||
4 d |
1 |
3 |
0 |
1 |
||||||||
7 d |
1 |
1 |
0 |
0 |
||||||||
Average: 24+48+72h |
2.0 |
3.3 |
0.0 |
1.0 |
Time to reversion |
Not reversible within 7 d |
Not reversible within 7 d |
- |
7 d |
|||
2
|
|
|
|
|
|
|
|
|||||
24 |
2 |
4 |
0 |
2 |
||||||||
48 |
3 |
4 |
0 |
1 |
||||||||
72 |
3 |
4 |
0 |
1 |
||||||||
4 d |
2 |
4 |
0 |
1 |
||||||||
7 d |
0 |
3 |
0 |
2 |
||||||||
Average: 24+48+72h |
2.3 |
4.0 |
0.0 |
1.3 |
Time to reversion |
7 d |
Not reversible within 7 d |
- |
Not reversible within 7 d |
|||
3
|
|
|
|
|
|
|
|
|||||
24 |
2 |
4 |
0 |
2 |
||||||||
48 |
3 |
4 |
0 |
2 |
||||||||
72 |
3 |
4 |
0 |
2 |
||||||||
4 d |
3 |
4 |
0 |
2 |
||||||||
7 d |
2 |
4 |
0 |
3 |
||||||||
Average: 24+48+72h |
2.3 |
4.0 |
0.0 |
2.0 |
Time to reversion |
Not reversible within 7 d |
Not reversible within 7 d |
- |
Not reversible within 7 d |
|||
4
|
|
|
|
|
|
|
|
|||||
24 |
2 |
4 |
0 |
2 |
||||||||
48 |
2 |
4 |
0 |
2 |
||||||||
72 |
2 |
4 |
0 |
2 |
||||||||
4 d |
1 |
3 |
0 |
2 |
||||||||
7 d |
0 |
2 |
0 |
2 |
||||||||
Average: 24+48+72h |
2.0 |
4.0 |
0.0 |
2.0 |
Time to reversion |
7 d |
Not reversible within 7 d |
- |
Not reversible within 7 d |
|||
5
|
|
|
|
|
|
|
|
|||||
24 |
2 |
4 |
1 |
2 |
||||||||
48 |
2 |
4 |
0 |
2 |
||||||||
72 |
2 |
4 |
0 |
2 |
||||||||
4 d |
2 |
4 |
0 |
2 |
||||||||
7 d |
0 |
3 |
0 |
1 |
||||||||
Average: 24+48+72h |
2.0 |
4.0 |
0.3 |
2.0 |
Time to reversion |
7 d |
Not reversible within 7 d |
48 h |
Not reversible within 7 d |
|||
6
|
|
|
|
|
|
|
|
|||||
24 |
3 |
4 |
1 |
2 |
||||||||
48 |
3 |
4 |
1 |
2 |
||||||||
72 |
3 |
4 |
1 |
2 |
||||||||
4 d |
2 |
4 |
1 |
3 |
|
|||||||
7 d |
1 |
4 |
0 |
2 |
|
|||||||
Average: 24+48+72h |
3.0 |
4.0 |
1.0 |
2.0 |
Time to reversion |
Not reversible within 7 d |
Not reversible within 7 d |
7 d |
Not reversible within 7 d |
|||
Mean out of all 6 rabbits |
24+48+72h |
2.67 |
3.88 |
0.2 |
1.7 |
|
Table2. Results of the washed eyes (30 s after instillation)
Rabbit #
|
Time [h]
|
conjunctivae
|
iris
|
cornea
|
|
conjunctivae
|
iris
|
cornea
|
||||
redness |
swelling |
redness |
swelling |
|||||||||
1
|
|
|
|
|
|
|
||||||
24 |
2 |
3 |
0 |
0 |
||||||||
48 |
0 |
2 |
0 |
0 |
||||||||
72 |
0 |
1 |
0 |
0 |
||||||||
4 d |
0 |
1 |
0 |
0 |
||||||||
7 d |
0 |
0 |
0 |
0 |
||||||||
Average: 24+48+72h |
0.67 |
2.0 |
0.0 |
0.0 |
Time to reversion |
48 h |
7 d |
- |
- |
|||
2
|
|
|
|
|
|
|
|
|||||
24 |
2 |
4 |
0 |
1 |
||||||||
48 |
2 |
4 |
0 |
1 |
||||||||
72 |
2 |
4 |
0 |
1 |
||||||||
4 d |
2 |
4 |
0 |
1 |
||||||||
7 d |
1 |
2 |
0 |
0 |
||||||||
Average: 24+48+72h |
2.0 |
4.0 |
0.0 |
1.0 |
Time to reversion |
Not reversible within 7 d |
Not reversible within 7 d |
- |
7 d |
|||
3
|
|
|
|
|
|
|
|
|||||
24 |
2 |
4 |
0 |
2 |
||||||||
48 |
3 |
4 |
0 |
2 |
||||||||
72 |
3 |
3 |
0 |
2 |
||||||||
4 d |
2 |
2 |
0 |
1 |
||||||||
7 d |
0 |
0 |
0 |
0 |
||||||||
Average: 24+48+72h |
2.67 |
3.67 |
0.0 |
2.0 |
Time to reversion |
7 d |
7 d |
- |
7 d |
|||
Mean out of all 6 rabbits |
24+48+72h |
1.78 |
3.22 |
0.0 |
1.0 |
|
Applicant's summary and conclusion
- Interpretation of results:
- Category 1 (irreversible effects on the eye) based on GHS criteria
- Conclusions:
- CLP: Eye damage 1, H318
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