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Diss Factsheets
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EC number: 203-813-0 | CAS number: 110-89-4
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Health surveillance data
Administrative data
- Endpoint:
- health surveillance data
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- study well documented, meets generally accepted scientific principles, acceptable for assessment
Data source
Referenceopen allclose all
- Reference Type:
- publication
- Title:
- Zur Problematik der Entwicklung eines biologischen Expositionstests bei Amin-Belastungen.
- Author:
- Heberer, H
- Year:
- 1 986
- Bibliographic source:
- Z. Klin. Med. 41, 143-146 (1986)
- Reference Type:
- publication
- Title:
- Chromatographic Methods for the Study of Amines from Biological Material
- Author:
- Blau K.
- Year:
- 1 961
- Bibliographic source:
- Biochem. J. 80: 193-200
Materials and methods
- Study type:
- health record, other
- Endpoint addressed:
- basic toxicokinetics
- Principles of method if other than guideline:
- Qualitative and quantitative determination of ammonia (NH₃) and amines in the urine according to Bittersohl and Heberer (Z.gesamte Hyg. 26 (1980), 258-259 and Heberer H et al., Z.gesamte Hyg. 25 (1979), 737-740). The determination of kreatinine was performed according to the Jaffé-reaction.
- GLP compliance:
- no
Test material
- Reference substance name:
- Piperidine
- EC Number:
- 203-813-0
- EC Name:
- Piperidine
- Cas Number:
- 110-89-4
- Molecular formula:
- C5H11N
- IUPAC Name:
- piperidine
Constituent 1
Method
- Type of population:
- general
- Details on study design:
- From 5 probands mean values of 5 urine samples per day collected at a given time over a period of 72 hours are given, respectively.
To assess the influence of diet on the excretion of amines, volunteers were fed with 100 g of pure Glucose per day for 72 hours under a safe exclusion of other foods with otherwise normal body burden.
Results and discussion
- Results:
- Mean values ± standard deviation of the concentration of piperidine in the urine of apparently healthy probands over a period of 72 hours; values in the brackets are the range; VK = variation coefficient:
Proband 1: 54.1 ± 25.7 µmol/L (10.7 - 94.0), VK 47.5
Proband 2: 55 ± 62.8 µmol/L (4.2 - 215), VK 115
Proband 3: 60.8 ± 32.6 µmol/L (22.7 - 129), VK 53.4
Proband 4: 28.5 ± 30.6 µmol/L (0.4 - 127), VK 107
Proband 5: 96.9 ± 86.6 µmol/L (29.1 - 368), VK 89.5
The content of piperidine in the urine depends crucially on the type and amount of food. Circannual differences in the amine excretion in individual subjects have so far not been demonstrated.
In accordance to Blau 1961 (Biochem.J. 80 (1961), 193-200), after fasting, a complete absence of piperidin exkretion was observed and attributed to the unavailability of lysine as a result of starvation.
Applicant's summary and conclusion
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