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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Endpoint:
acute toxicity: oral
Type of information:
experimental study
Adequacy of study:
key study
Study period:
Not reported
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
study well documented, meets generally accepted scientific principles, acceptable for assessment

Data source

Referenceopen allclose all

Reference Type:
publication
Title:
Acute Toxicity of Zirconium, Columbium, Strontium, Lanthanum, Cesium, Tantalum and Yttrium.
Author:
Cochran K W, Doull J, Mazur M & DuBois K P
Year:
1950
Bibliographic source:
Archive of Industrial Hygiene and Occupational Medicine 1:637-650
Reference Type:
secondary source
Title:
Patty's Industrial Hygiene and Toxicology Third Revised Edition
Author:
Clayton
Year:
1981
Bibliographic source:
Patty's Industrial Hygiene and Toxicology Third Revised Edition, Clayton GD, Clayton FE (ed.), John Wiley & Sons, 1981, p1906-1914
Reference Type:
secondary source
Title:
Metal Toxicity in Mammals 2, chemical Toxicity of Metals and Metalloids
Author:
Venugopal B & Luckey T
Year:
1978
Bibliographic source:
Ch. 5, pg. 231
Reference Type:
secondary source
Title:
The Merck Index 14th Edition An Encyclopedia of Chemicals, Drugs and Biologicals
Author:
O'Neil M (ed), Heckelman P E, Kock C B, Roman K J, Kenny C M & D'Arecca M R
Year:
2006
Bibliographic source:
Merck Research Laboratories Division of Merck & Co., Inc., Whitehouse Station, NJ, USA Pg. 9054

Materials and methods

Principles of method if other than guideline:
Test guidelines not mentioned in the literature.
GLP compliance:
not specified
Test type:
other: Not reported

Test material

Constituent 1
Chemical structure
Reference substance name:
Ditantalum pentaoxide
EC Number:
215-238-2
EC Name:
Ditantalum pentaoxide
Cas Number:
1314-61-0
Molecular formula:
O5Ta2
IUPAC Name:
ditantalum(5+) pentaoxidandiide
Test material form:
not specified

Test animals

Species:
rat
Strain:
Sprague-Dawley
Sex:
male/female
Details on test animals or test system and environmental conditions:
TEST ANIMALS
- Source: Not reported
- Age at study initiation: Adult
- Weight at study initiation: 200-300 g
- Diet (e.g. ad libitum): Purina chow given ad libitum
- Water (e.g. ad libitum): ad libitum

ENVIRONMENTAL CONDITIONS
- Maintained in an air conditioned room.

Administration / exposure

Route of administration:
oral: gavage
Vehicle:
water
Doses:
Single dose
Details on study design:
Animals were observed for 10 days. A preliminary study was carried out for 30 days to determine an observation period.

Results and discussion

Effect levels
Key result
Sex:
male/female
Dose descriptor:
LD0
Effect level:
>= 8 000 mg/kg bw
Based on:
test mat.
Other findings:
No significant observations were made over the 10 day period.

Applicant's summary and conclusion

Interpretation of results:
not classified
Remarks:
Migrated information Criteria used for interpretation of results: EU
Conclusions:
Tantalum oxide was recorded to have an LD0 of >= 8000 mg/kg after a single dose was administered to rats.
Executive summary:

Tantalum oxide was administered orally to rats in an acute toxicity study. There are limited methodological details provided. No standard guideline procedure was mentioned. The LD₀ was recorded as >= 8000 mg/kg of tantalum oxide, which is above the limits of classification. Tantalum oxide therefore does not require classification according to Regulation (EC) No.1272/2008.