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EC number: 234-205-3 | CAS number: 10595-60-5
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Study period:
- Not reported
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: see 'Remark'
- Remarks:
- Study conducted in accordance with generally accepted scientific principles, with incomplete reporting or methodological deficiencies. This reference does not provide a full report with regard to the methods used in this study. Most basic key information is reported.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 981
- Report date:
- 1981
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: Modified I.R.L.G. Guidelines Method
- Deviations:
- not specified
- Principles of method if other than guideline:
- A single limit dose was applied to the abraded skin of male and female rabbits under a semi-occlusive dressing for 24 hours. The animals were observed for 14 days.
- GLP compliance:
- not specified
- Test type:
- standard acute method
- Limit test:
- yes
Test material
- Reference substance name:
- N,N'-bis(1,3-dimethylbutylidene)-2,2'-iminobis(ethylamine)
- EC Number:
- 234-205-3
- EC Name:
- N,N'-bis(1,3-dimethylbutylidene)-2,2'-iminobis(ethylamine)
- Cas Number:
- 10595-60-5
- Molecular formula:
- C16H33N3
- IUPAC Name:
- N-(1,3-dimethylbutylidene)-N'-{2-[(1,3-dimethylbutylidene)amino]ethyl}ethane-1,2-diamine
- Test material form:
- other: watery liquid
- Details on test material:
- - Physical details: light amber, watery liquid with a highly noticeable odour.
- Storage conditions: ambient room temperature
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- New Zealand White
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Diet (e.g. ad libitum): ad libitum Wayne diet
- Water (e.g. ad libitum): ad libitum
Administration / exposure
- Type of coverage:
- semiocclusive
- Vehicle:
- unchanged (no vehicle)
- Details on dermal exposure:
- TEST SITE
- Area of exposure: 240 cm² dorsal area, abraded
- Type of wrap if used: porous gauze dressing covered by a semi-occlusive wrapping of polyethylene sheeting.
REMOVAL OF TEST SUBSTANCE
- Washing (if done): excess fluid is removed to prevent ingestion.
- Time after start of exposure: following removal of the semi-occlusive dressing after 24 hours.
TEST MATERIAL
- Amount(s) applied (volume or weight with unit): 2.0 mL/kg
RESTRAINTS
Rabbits were restrained in a hood for the 24 hour contact period due to a danger of inhaling vapours from the test material. - Duration of exposure:
- 24 hours
- Doses:
- 2.0 mL/kg
- No. of animals per sex per dose:
- 2 animals per sex per dose
- Control animals:
- not specified
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations and weighing: no data
- Necropsy of survivors performed: yes
- Other examinations performed: clinical signs and bodyweight - Statistics:
- LD50 is calculated by probit transformation based on 14 days’ observation.
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 2 mL/kg bw
- Based on:
- test mat.
- Mortality:
- There was no mortality seen.
- Clinical signs:
- other: The dosed animals had severe erythema within 1 hour and severe eschar and necrosis as a result of the 24 hour application. Scabbing and ulceration of the skin was seen by day 7. Hyperactivity was seen in the animals immediately after dosing. At 24 hours,
- Gross pathology:
- Kidney and lung pathology was evident at necropsy.
-One male animal had rounded, swollen and yellow kidneys; one female exhibited flattened, swollen and tan kidneys. One male and one female had kidneys with pitted surfaces.
-One male had a dark red upper right lobe of the lung; the other male had dark red lower lobes. One female showed brownish red lower lobes of the lungs.
Applicant's summary and conclusion
- Conclusions:
- Under the conditions of this study the LD50 was determined to be >2.0 mL/kg, dosed undiluted.
- Executive summary:
The acute dermal toxicity of the test material was investigated in accordance with a modified I.R.L.G. Guidelines method.
A single limit dose of 2.0 mL/kg was applied to the abraded skin of 2 male and 2 female albino rabbits under a semi-occlusive dressing for 24 hours. The animals were observed for 14 days.
No mortality was seen though severe skin reactions were seen in all dosed animals. Kidney and lung pathology was evident at necropsy.
Under the conditions of this study the LD50 was determined to be >2.0 mL/kg, dosed undiluted.
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