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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Endpoint:
acute toxicity: other routes
Type of information:
experimental study
Adequacy of study:
supporting study
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
other: No data about guideline followed

Data source

Reference
Reference Type:
other: book
Title:
Summary Tables of Biological Tests
Author:
National Research Council Chemical-Biological Coordination Center
Year:
1953
Bibliographic source:
"Summary Tables of Biological Tests," National Research Council Chemical-Biological Coordination Center. Vol. 5, Pg. 340, 1953.

Materials and methods

Test material

Constituent 1
Chemical structure
Reference substance name:
1,1'-isopropylidenebis(p-phenyleneoxy)dipropan-2-ol
EC Number:
204-137-9
EC Name:
1,1'-isopropylidenebis(p-phenyleneoxy)dipropan-2-ol
Cas Number:
116-37-0
Molecular formula:
C21H28O4
IUPAC Name:
1,1'-isopropylidenebis(p-phenyleneoxy)dipropan-2-ol

Test animals

Species:
mouse
Strain:
not specified
Sex:
not specified
Details on test animals or test system and environmental conditions:
no data

Administration / exposure

Route of administration:
intraperitoneal
Vehicle:
propylene glycol
Details on exposure:
no data
Doses:
no data
No. of animals per sex per dose:
five animals were tested but no data on sex or doses is available
Control animals:
not specified

Results and discussion

Effect levels
Sex:
not specified
Dose descriptor:
LD0
Effect level:
>= 500 mg/kg bw
Based on:
act. ingr.
Mortality:
No mortality observed in any of the 5 animals tested.
Clinical signs:
Details of toxic effects not reported other than lethal dose value
Body weight:
No data
Gross pathology:
No data
Other findings:
No data

Applicant's summary and conclusion

Conclusions:
The application of 500 mg/Kg bw did not produce mortality in this study in any of the 5 animals tested.
Executive summary:

The data published reports no mortality on 5 mouse tested at 500 mg/Kg by intraperitioneal route. Details of toxic effects not reported other than lethal dose value. No data on sex, strains, or body weight of animals are provided.