Registration Dossier
Registration Dossier
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EC number: 203-629-0 | CAS number: 108-91-8
Genetic toxicity: in vitro
Administrative data
- Endpoint:
- in vitro gene mutation study in bacteria
- Remarks:
- Type of genotoxicity: gene mutation
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: guideline study
Data source
Reference
- Reference Type:
- publication
- Title:
- Salmonella mutaginicity tests: II. Results from the testing of 270 chemicals
- Author:
- Mortelmans K, Haworth St, Lawlor T, Speck W
- Year:
- 1 986
- Bibliographic source:
- Environ. Mutagen. 8, Suppl. 7, 1-119
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 471 (Bacterial Reverse Mutation Assay)
- Principles of method if other than guideline:
- Preincubation protocoll
- GLP compliance:
- not specified
- Type of assay:
- other: Salmonella/microsome assay
Test material
- Reference substance name:
- Cyclohexylamine
- EC Number:
- 203-629-0
- EC Name:
- Cyclohexylamine
- Cas Number:
- 108-91-8
- Molecular formula:
- C6H13N
- IUPAC Name:
- cyclohexanamine
- Details on test material:
- purity 98 %
Constituent 1
Method
Species / strain
- Species / strain / cell type:
- other: Salmonella typhimurium TA 98, TA 100, TA 1535, TA 1537
- Additional strain / cell type characteristics:
- other: Salmonella typhimurium TA 98, TA 100, TA 1535, TA 1537
- Metabolic activation:
- with and without
- Metabolic activation system:
- S9-mix form male Sprague-Dawley rats and from male Syrian hamsters , both induced with Aroclor 1254
- Test concentrations with justification for top dose:
- 0, 33, 100, 333,1000, 3333, 10000 µg/plate
- Vehicle / solvent:
- water
Controls
- Untreated negative controls:
- yes
- Negative solvent / vehicle controls:
- yes
- True negative controls:
- other: potassiumchloride
- Positive controls:
- yes
- Positive control substance:
- other: 9-aminoacridine, sodium azide, 4-nitro-o-phenylenediamine, 2-aminoanthracene
- Details on test system and experimental conditions:
- preincubation protocoll
- Evaluation criteria:
- mutagenic response: a dose related reproducible increase in the numger of revertants over the background even if the increase was less than 2-fold
- Statistics:
- no data
Results and discussion
Test results
- Species / strain:
- other: Salmonella typhimurium TA 98, TA 97, TA 100, TA 1535, TA 1537
- Metabolic activation:
- with and without
- Genotoxicity:
- negative
- Cytotoxicity / choice of top concentrations:
- cytotoxicity
- Vehicle controls validity:
- valid
- Untreated negative controls validity:
- valid
- Positive controls validity:
- valid
- Remarks on result:
- other: other: Salmonella typhimurium TA 98, TA 97, TA 100, TA 1535, TA 1537
- Remarks:
- Migrated from field 'Test system'.
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
