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Diss Factsheets
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EC number: 214-729-9 | CAS number: 1191-15-7
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
The substance is pyrophoric, water reactive and corrosive
Key value for chemical safety assessment
Skin sensitisation
Link to relevant study records
- Endpoint:
- skin sensitisation: in vitro
- Data waiving:
- study technically not feasible
- Justification for data waiving:
- the study does not need to be conducted because the substance is spontaneously flammable in air or in contact with water or moisture at room temperature
- Interpretation of results:
- other: Waiver
- Conclusions:
- Corrosive. Flammable in air at room temperature. Thus, exposure of mammalian species to aluminum alkyls would notgenerate meaningful data, and no skin sensitization studies arerequired for this substance.
- Executive summary:
Corrosive. Flammable in air at room temperature. Thus, exposure of mammalian species to aluminum alkyls would notgenerate meaningful data, and no skin sensitization studies arerequired for this substance.
Reference
Endpoint conclusion
- Additional information:
Corrosive. Flammable in air at room temperature.
Most of the chemistry of organoaluminum compounds can be explained in terms of the Lewis acidity of organoaluminum monomers, directly related to the tendency of the aluminum atom to build up an octet of electrons. Reactions of these substances are explosive. The alkyl aluminums are highly reactive towards oxidizing agents including molecular oxygen, thus, the fast reactions in air.
Reactions with Oxygen (air) - this reaction is vigorous and will generally cause the material to ignite resulting in a fire difficult to extinguish.
Reactions with Water - this reaction is even more violent than those with oxygen. The reaction causes flammable gases that are easily ignited by the fire already created by the organoaluminum compound with water.
Thus, exposure of mammalian species to aluminum alkyls would not generate meaningful data, and no skin sensitization studies are required for this substance.
Migrated from Short description of key information:
Corrosive. Flammable in air at room temperature. According to the Annex VII Standard Information Requirements for REACH, as step 2 of the assessment of skin sensitization endpoint, in vivo testing for skin sensitization is required. A specific rule for adaptation for an in vivo skin sensitization test states that the study does not need to be conducted if – the available information indicates that the substance should be classified for skin sensitizatin or corrosivity; or – the substance is a strong acid (pH < 2.0) or base (pH > 11.5); or - the substance is flammable in air at room temperature.
Aluminum alkyls are highly reactive substances both in air and in contact to water, causing explosive or flammable situations as explained below. They are well known to cause burns to skin and eyes, and are flammable in air and water. Thus, skin sensitization tests are technically not feasible to conduct and are scientifically unjustified.
Respiratory sensitisation
Endpoint conclusion
- Additional information:
No data. Substance is corrosive and flammable in air at room temperature.
Justification for classification or non-classification
The substance is pyrophoric, water reactive and corrosive.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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