Registration Dossier
Registration Dossier
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EC number: 253-138-0 | CAS number: 36631-30-8
Endpoint summary
Administrative data
Description of key information
Additional information
An acute fish toxicity test was conducted with the test substance, triisodecyl benzene-1,2,4-tricarboxylate according to EEC-Guideline L251 Vol. 27, 84/449/EEC: C (static procedure). No mortalities occurred. The 96 hour LC50 for the substance was > 1000 mg/L. Toxicity to fish of read-across substance, tris(2-ethylhexyl)benzene-1,2,4-tricarboxylate, has been investigated in 14 day test according to OECD test methods. Dissolution/dispersion agents were used to increase concentration of the substance in the test medium. The 14 day NOEC was determined to be >75.0 mg/L. It is recognised that the duration of the OECD TG 204 test is shorter than that currently accepted for investigating long-term toxicity in fish. Waiving of additional testing is proposed based both on the lack of effects seen in the 14-day fish study and chronic Daphnia reproduction study.
Acute immobilisation in Daphnia has been investigated with read-across substance, tris(2-ethylhexyl)benzene-1,2,4-tricarboxylate, in a 48 hour test conducted according to OECD test methods. Dissolution/dispersion agents were used to increase concentration of the substance in the test medium. The EC50 (48h) was determined to be >180 mg/L and the NOEC was 180 mg/L, the highest concentration investigated. In an acute Daphnia toxicity study conducted with the test substance, triisodecyl benzene-1,2,4-tricarboxylate, the 24 h EC50 value was 1.5 mg/L, however, there was test substance floating on surface of water at 5.8 mg/L (nominal) after 24 h exposure, which may have affected mobility of Daphnia, therefore the results of this study are not considered to be reliable.
Chronic toxicity to Daphnia has been investigated in a 21-day reproduction test according to OECD test methods with read-across substance, tris(2-ethylhexyl)benzene-1,2,4-tricarboxylate. Dissolution/dispersion agents were used to increase concentration of the substance in the test medium. The following values were calculated: NOEC (21 -day, reproduction): 55.6 mg/L; LOEC (21 -day, reproduction): >100 mg/L; EC50 (21 -day, reproduction): 89.1 mg/L.
The effect of read-across substance, tris(2-ethylhexyl) benzene-1,2,4-tricarboxylate, on algae growth has been investigated in a 72 hour test according to OECD test methods. Dissolution/dispersion agents were used to increase concentration of the substance in the test medium. The EC50 (72h) was determined to be >100 mg/L and the NOEC was 100 mg/L, the highest concentration examined.
The read-across substance, tris(2-ethylhexyl) benzene-1,2,4-tricarboxylate, is not toxic at concentrations up to 1000 mg/L to activated sludge of a municipal sewage treatment plant.
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