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EC number: 271-802-8 | CAS number: 68608-82-2 A complex combination of hydrocarbons obtained by the alkylation of benzene with ethene. It consists primarily of ethylbiphenyls, diethylbenzenes with lesser amounts of butylbenzenes and polyethylbenzenes.
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1985
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: Well conducted and reported study according to the standard guideline
Cross-referenceopen allclose all
- Reason / purpose for cross-reference:
- reference to same study
- Reason / purpose for cross-reference:
- reference to other study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 985
- Report date:
- 1985
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- EPA OPP 81-1 (Acute Oral Toxicity)
- Principles of method if other than guideline:
- Not applicable
- GLP compliance:
- not specified
- Test type:
- standard acute method
- Limit test:
- yes
Test material
- Details on test material:
- Test substance: MCS-2170
Physical state: Yellow Liquid
Reference Number: NBP-2532690-B
Stored at Room Temperature
Density 0.97 g/ml
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Crj: CD(SD)
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Charles River Laboratory
- Age at study initiation: 9-12 weeks
- Weight at study initiation: 301-325 g (males) 236-260g (females)
- Fasting period before study: overnght (approx 18 hours)
- Housing: Individually hosed during study in stainless steel cages
- Diet: ad libitum Purina Laboratory Chow
- Water: ad libitum
- Acclimation period: 16 days
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 67-76 Deg Farenheit
- Humidity (%): 30-70%
- Photoperiod (hrs dark / hrs light): 12h day/night cycle
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- unchanged (no vehicle)
- Details on oral exposure:
- Adminstration via a ball tiped gavage needle. Doses calculated using fasted body weights. Dose volume 5.2 ml/kg.
- Doses:
- 5000 mg/kg bw
- No. of animals per sex per dose:
- 5
- Control animals:
- no
- Details on study design:
- Observations made approximately 1, 2, and 4 hours after dosing thereafter every day, 2 times per day.
Body weights taken at start of study and on day 7 and 14.
All animals surviving to day 14 were sacrificed (Carbon Dioxide inhalation)
Gross examinations performed, abnormalities recorded but no tissues saved. - Statistics:
- Not applicable
Results and discussion
- Preliminary study:
- Not applicable
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 5 000 mg/kg bw
- Remarks on result:
- other: no mortality observed
- Mortality:
- All animals survived
- Clinical signs:
- other: Most animals were free of abnormalities on the day of dosing, although a few exhibited wet rales or nasal discharge. However, a number of unusual signs were seen beginning on the day after dosing. These included urinary and fecal staining in most animals;
- Gross pathology:
- Gross postmortem observations were similar to those seen in control animals in this laboratory or were considered to represent normal physiological variation.
- Other findings:
- Not applicable
Any other information on results incl. tables
DOSE: 5000 mglkg
SUMMARY OF PHARMACOLOGIC AND TOXICOLOGIC SIGNS
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Day |
|
|
|
1 |
2 |
3 |
4 |
5 |
6 |
7 |
8 |
9 |
10 |
11 |
12 |
13 |
14 |
Hour |
1 |
2 |
4 |
24 |
|
|
|
|
|
|
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|
|
|
|
|
Observation |
M/F |
M/F |
M/F |
M/F |
M/F |
M/F |
M/F |
M/F |
M/F |
M/F |
M/F |
M/F |
M/F |
M/F |
M/F |
M/F |
M/F |
Nasal Discharge
|
-/1 |
- |
- |
1/1 |
- |
1/- |
- |
- |
- |
- |
|
|
|
- |
|
- |
- |
Oral Discharge (salivation)
|
- |
- |
- |
4/1 |
2/- |
1/- |
- |
- |
- |
- |
- |
- |
- |
- |
- |
- |
- |
Met Rales
|
- |
1/1 |
1/1 |
1/1 |
-/1 |
- |
- |
- |
- |
|
|
- |
- |
- |
|
- |
- |
Urinary Staining
|
- |
- |
- |
4/5 |
2/1 |
- |
- |
- |
- |
- |
- |
- |
- |
- |
|
- |
- |
Fecal Staining
|
- |
- |
- |
4/2 |
2/1 |
- |
- |
- |
- |
- |
- |
- |
- |
- |
|
|
|
Unthrifty Coat
|
- |
- |
- |
3/- |
4/4 |
4/5 |
2/2 |
2/1 |
- |
|
|
- |
- |
- |
- |
- |
|
Soft Stool
|
- |
- |
- |
1/1 |
-/1 |
- |
- |
- |
- |
- |
- |
- |
- |
- |
- |
- |
- |
Alopecia
|
- |
- |
- |
- |
- |
- |
- |
-/1 |
1/2 |
-/3 |
-/3 |
¼ |
2/4 |
2/4 |
2/4 |
2/4 |
3/4 |
Hypoactivity
|
- |
- |
- |
2/2 |
2/2 |
1/2 |
- |
- |
- |
- |
- |
- |
- |
|
- |
|
|
Food Consumption Decreaseb
|
- |
- |
- |
-/1 |
-/1 |
2/2 |
1/2 |
- |
- |
- |
- |
- |
- |
1/- |
- |
- |
- |
Lesion Right Hind Leg
|
- |
- |
- |
- |
- |
1/- |
1/- |
1/- |
1/- |
1/- |
1/- |
1/- |
- |
- |
- |
- |
- |
aNumbers represent number of males and females(M/F),out of 5 per sex which exhibited signs one or more times during interval.
bVisua1 assessment; no food consumption measurements made.
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- The Oral LD50 value of this substance is >5 g/kg bw.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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