Registration Dossier
Registration Dossier
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EC number: 244-017-3 | CAS number: 20769-85-1
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 1 (reliable without restriction)
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 999
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 404 (Acute Dermal Irritation / Corrosion)
- Qualifier:
- according to guideline
- Guideline:
- EU Method B.4 (Acute Toxicity: Dermal Irritation / Corrosion)
- GLP compliance:
- yes (incl. QA statement)
Test material
- Reference substance name:
- 2-bromo-2-methylpropionyl bromide
- EC Number:
- 244-017-3
- EC Name:
- 2-bromo-2-methylpropionyl bromide
- Cas Number:
- 20769-85-1
- Molecular formula:
- C4H6Br2O
- IUPAC Name:
- 2-bromo-2-methylpropanoyl bromide
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- New Zealand White
Test system
- Type of coverage:
- semiocclusive
- Preparation of test site:
- other: clipped using elctric clippers
- Vehicle:
- unchanged (no vehicle)
- Controls:
- yes, concurrent no treatment
- Amount / concentration applied:
- 0,5 mL of the test substance applied to a 6 cm2 dry gauze pad
- Duration of treatment / exposure:
- 4 hours
- Observation period:
- 4 hours
- Number of animals:
- 3 foreseen, 1 effectively used
Results and discussion
In vivo
Results
- Irritation parameter:
- other: Visual observation
- Basis:
- mean
- Time point:
- other: On removal of the deressing after 4 hours
- Remarks on result:
- other: Test substance is corrosive : thickness destruction observed
Applicant's summary and conclusion
- Interpretation of results:
- corrosive
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- Under our experimental conditions, the test substance 2-bromoisobutyryl bromide is corrosive when applied topically to rabbits.
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