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Diss Factsheets
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EC number: 202-829-5 | CAS number: 100-20-9
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Repeated dose toxicity: inhalation
Administrative data
- Endpoint:
- short-term repeated dose toxicity: inhalation
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- study well documented, meets generally accepted scientific principles, acceptable for assessment
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 971
- Report date:
- 1971
Materials and methods
- Principles of method if other than guideline:
- Six male rats were exposed whole body to the test substance for four hours per day for ten days. Six control rats were exposed to air for the same period of time. Gross and histopathologic examinations were performed on three rats from each group after the last exposure and 14 days post-exposure.
- GLP compliance:
- no
Test material
- Reference substance name:
- Terephthaloyl dichloride
- EC Number:
- 202-829-5
- EC Name:
- Terephthaloyl dichloride
- Cas Number:
- 100-20-9
- Molecular formula:
- C8H4Cl2O2
- IUPAC Name:
- benzene-1,4-dicarbonyl dichloride
- Reference substance name:
- Terephthaloyl chloride
- IUPAC Name:
- Terephthaloyl chloride
- Details on test material:
- - Purity: 99.9%
Constituent 1
Constituent 2
Test animals
- Species:
- rat
- Strain:
- other: ChR-CD
- Sex:
- male
Administration / exposure
- Route of administration:
- inhalation: aerosol
- Type of inhalation exposure:
- whole body
- Vehicle:
- other: air (nitrogen carried aerosol into test chamber where it was then mixed with additional oxygen and diluting air to achieve a 20% O2 (v/v) level)
- Analytical verification of doses or concentrations:
- yes
- Duration of treatment / exposure:
- 4 hours
- Frequency of treatment:
- One time per day for 10 days
Doses / concentrations
- Dose / conc.:
- 0.087 other: ± 0.010 mg/L
- Remarks:
- average concentration
- No. of animals per sex per dose:
- 6
- Control animals:
- yes, sham-exposed
Results and discussion
Results of examinations
- Description (incidence and severity):
- During exposure period rats did not gain weight normally; during post exposure weight gain was normal.
- Description (incidence and severity):
- No significant histopathological changes.
Effect levels
- Dose descriptor:
- dose level:
- Effect level:
- 0.087 mg/L air
- Sex:
- male
- Basis for effect level:
- other: suppressed growth rate during exposures; growth rate normal during recovery
Target system / organ toxicity
- Critical effects observed:
- no
Applicant's summary and conclusion
- Conclusions:
- In rats exposed by inhalation to 0.087 mg/L for four hours for ten days weight gain suppression was observed during exposure and was normal during recovery. No significant treatment related histophathological changes were found.
- Executive summary:
Six male rats were exposed whole body to 0.087 mg/L of the test substance for four hours per day for ten days. Six control rats were exposed to air for the same period of time. Gross and histopathologic examinations were performed on three rats from each group after the last exposure and 14 days post-exposure. In rats exposed by inhalation to 0.087 mg/L for four hours for ten days weight gain suppression was observed during exposure and was normal during recovery. No significant treatment related histophathological changes were found.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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