3-Morpholinone, 4-phenyl-

Short-term toxicity to aquatic invertebrates

Administrative data

Endpoint:

short-term toxicity to aquatic invertebrates

Type of information:

experimental study

Adequacy of study:

other information

Study period:

2007-01-25 to 2007-02-26

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

other: Study conducted according to guideline under GLP

Data source

Reference

Reference Type:

study report

Title:

Unnamed

Year:

2007

Report date:

2007

Materials and methods

Test guideline

Qualifier:

according to guideline

Guideline:

OECD Guideline 202 (Daphnia sp. Acute Immobilisation Test)

Deviations:

no

GLP compliance:

yes (incl. QA statement)

Test material

Test material information

Constituent 1

Reference substance name:

4-phenylmorpholin-3-one

EC Number:

608-371-6

Cas Number:

29518-11-4

Molecular formula:

C10 H11 N O2

IUPAC Name:

4-phenylmorpholin-3-one

Details on test material:

- Name of test material (as cited in study report): 4-Phenyl-3-Morpholinon
- Lot/batch No.: BXR2Z1A

Sampling and analysis

Analytical monitoring:

yes

Test solutions

Vehicle:

no

Test organisms

Test organisms (species):

Daphnia magna

Study design

Test type:

static

Water media type:

freshwater

Limit test:

yes

Total exposure duration:

48 h

Results and discussion

Effect concentrations

Duration:

48 h

Dose descriptor:

LC50

Effect conc.:

> 99.6 mg/L

Nominal / measured:

meas. (arithm. mean)

Conc. based on:

test mat.

Basis for effect:

mobility

Any other information on results incl. tables

No immobilization of daphnids could be observed.

Applicant's summary and conclusion

Validity criteria fulfilled:

yes

Conclusions:

No toxic effects against daphnia at a limit test concentration of 100 mg/L.

Executive summary:

A study was performed to assess the acute toxicity of 4-Phenyl-3-Morpholinon to daphnia magna under static conditions. The study was conducted in accordance with the OECD Guideline for Testing of Chemicals No. 202 ´Daphnia sp., Acute Immobilization Test´ (adopted April 13, 2004).

The Daphnia were exposed in two replicates to a limit test concentration of 4-Phenyl-3-Morpholinon (100 mg/L) dissolved in water over 48 hours. Auxiliary used to prepare the test media was an ultrasonic bath.

Observations were made on the swimming ability and the immobilization rate, respectively, after 24 and 48h of exposure. No toxic effects against daphnia at a nominal limit test concentration of 100 mg/L could be observed. Recovery rates correspond to 100.4% of nominal values at 0h and 99.6% at 48h, respectively.