Registration Dossier
Registration Dossier
Data platform availability banner - registered substances factsheets
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 918-973-3 | CAS number: 1174522-45-2
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
![](https://echa.europa.eu/o/diss-blank-theme/images/factsheets/A-REACH/factsheet/print_toxicological-information.png)
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- From the 14th to the 28th of June 1983
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: see 'Remark'
- Remarks:
- No guideline claimed but test procedure in accordance with guideline and described in sufficient details. Substance analytical certificate not available. Test substance information available from the manufacturer for code name (C14-C17 normal Paraffins)
- Justification for type of information:
- A discussion and report on the read across strategy is given as an attachment in IUCLID Section 13.
Cross-reference
- Reason / purpose for cross-reference:
- read-across: supporting information
Reference
- Endpoint:
- acute toxicity: oral
- Type of information:
- read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- key study
- Study period:
- From the 14th to the 28th of June 1983
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: see 'Remark'
- Remarks:
- No guideline claimed but test procedure in accordance with guideline and described in sufficient details. Substance analytical certificate not available. Test substance information available from the manufacturer for code name (C14-C17 normal Paraffins)
- Justification for type of information:
- A discussion and report on the read across strategy is given as an attachment in IUCLID Section 13.
- Reason / purpose for cross-reference:
- read-across source
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 401 (Acute Oral Toxicity)
- Principles of method if other than guideline:
- Guideline principles
- GLP compliance:
- no
- Test type:
- standard acute method
- Limit test:
- yes
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Taconic Farms, Germantown, New York
- Age at study initiation: 10-11 weeks of age
- Weight at study initiation: 189 to 317 grams
- Fasting period before study: overnight
- Housing: suspended stainless steel
- Diet (e.g. ad libitum): Purina rodent chow ad libitum
- Water (e.g. ad libitum): yes
- Acclimation period: 21 days
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 20 to 24
- Humidity (%): 40 to 70
- Air changes (per hr): no data
- Photoperiod (hrs dark / hrs light): 12/12
IN-LIFE DATES: From: 14 June 1983 To: 28 June 1983 - Route of administration:
- oral: gavage
- Vehicle:
- unchanged (no vehicle)
- Details on oral exposure:
- No additional data
- Doses:
- 5000 mg/kg bw
- No. of animals per sex per dose:
- 5 rats/sex/dose (see Table 7.2.1/1)
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations and weighing: 1, 2, 4, 6 hours after dosing and once per day thereafter, body weights: prior to dosing and at day 7 and 14.
- Necropsy of survivors performed: yes
- Other examinations performed: clinical signs, body weight,organ weights, histopathology, other: - Statistics:
- no data
- Preliminary study:
- no additional data
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 5 000 mg/kg bw
- Mortality:
- No mortality was observed during the study
- Clinical signs:
- other: There were few clinical in-life observations during the test period. A/G staining was observed in 5 males and 4 females animals at the 4 hour observation and in 5 males and 5 females at the 6 hours observation. Unthrifty coat was observed in 2 males and
- Gross pathology:
- The only gross post mortem observation noted at necropsy was lung discoloration in 7 of the 10 test animals.
- Other findings:
- No additional data
- Interpretation of results:
- other: Practically non toxic
- Remarks:
- Criteria used for interpretation of results: EU
- Conclusions:
- Under the test conditions, MRD-83-207 is not classified according to the criteria of Annex VI to the Directive 67/548/EEC and CLP Regulation 1272/2008.
- Executive summary:
MRD-83-207 was tested for acute oral toxicity in Sprague-Dawley rats in a limit dose assay.
The test substance, a liquid, was administered as supplied. Animals were fasted overnight prior to treatment. The assay was conducted on a group of 10 rats (5 males, 5 females) with a dose of 5000 mg/kg b.w. administered by gavage (via a syringe) in a single oral dose.
Examinations for mortality, clinical signs and body weight gain were performed during the 14-day observation period. All surviving animals were necropsied at the end of the observation period.
No deaths occurred during the study. Body weight gain was not affected by treatment. A/G staining was noted in all animals within the 6-hour observation period. In-life observations also included alopecia and unkempt coat. At necropsy, macroscopic examination of main organs showed lung discoloration in seven animals.
As the acute oral LD50 was found to be greater than 5000 mg/kg b.w. under the conditions of the test, MRD-83-207 is not classified according to the criteria of Annex VI to Directive 67/548/EEC and CLP Regulation 1272/2008.
No additional data
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 983
- Report date:
- 1983
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 401 (Acute Oral Toxicity)
- Principles of method if other than guideline:
- Guideline principles
- GLP compliance:
- no
- Test type:
- standard acute method
- Limit test:
- yes
Test material
- Reference substance name:
- Paraffin (petroleum), normal, C5-C20
- IUPAC Name:
- Paraffin (petroleum), normal, C5-C20
- Reference substance name:
- MRD-83-207
- IUPAC Name:
- MRD-83-207
- Details on test material:
- - Name of test material (as cited in study report): MRD-83-207
- Substance type: Petroleum product, UVCB
- Physical state: clear liquid (density = 0.76 g/mL at room temperature)
- Analytical purity: 100% Commercial product (100% purity assumed for dosing)
- Composition of test material, percentage of components: C14-C17 normal Paraffins
Constituent 1
Constituent 2
Test animals
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Taconic Farms, Germantown, New York
- Age at study initiation: 10-11 weeks of age
- Weight at study initiation: 189 to 317 grams
- Fasting period before study: overnight
- Housing: suspended stainless steel
- Diet (e.g. ad libitum): Purina rodent chow ad libitum
- Water (e.g. ad libitum): yes
- Acclimation period: 21 days
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 20 to 24
- Humidity (%): 40 to 70
- Air changes (per hr): no data
- Photoperiod (hrs dark / hrs light): 12/12
IN-LIFE DATES: From: 14 June 1983 To: 28 June 1983
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- unchanged (no vehicle)
- Details on oral exposure:
- No additional data
- Doses:
- 5000 mg/kg bw
- No. of animals per sex per dose:
- 5 rats/sex/dose (see Table 7.2.1/1)
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations and weighing: 1, 2, 4, 6 hours after dosing and once per day thereafter, body weights: prior to dosing and at day 7 and 14.
- Necropsy of survivors performed: yes
- Other examinations performed: clinical signs, body weight,organ weights, histopathology, other: - Statistics:
- no data
Results and discussion
- Preliminary study:
- no additional data
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 5 000 mg/kg bw
- Mortality:
- No mortality was observed during the study
- Clinical signs:
- other: There were few clinical in-life observations during the test period. A/G staining was observed in 5 males and 4 females animals at the 4 hour observation and in 5 males and 5 females at the 6 hours observation. Unthrifty coat was observed in 2 males and
- Gross pathology:
- The only gross post mortem observation noted at necropsy was lung discoloration in 7 of the 10 test animals.
- Other findings:
- No additional data
Any other information on results incl. tables
No additional data
Applicant's summary and conclusion
- Interpretation of results:
- other: Practically non toxic
- Remarks:
- Criteria used for interpretation of results: EU
- Conclusions:
- Under the test conditions, MRD-83-207 is not classified according to the criteria of Annex VI to the Directive 67/548/EEC and CLP Regulation 1272/2008.
- Executive summary:
MRD-83-207 was tested for acute oral toxicity in Sprague-Dawley rats in a limit dose assay.
The test substance, a liquid, was administered as supplied. Animals were fasted overnight prior to treatment. The assay was conducted on a group of 10 rats (5 males, 5 females) with a dose of 5000 mg/kg b.w. administered by gavage (via a syringe) in a single oral dose.
Examinations for mortality, clinical signs and body weight gain were performed during the 14-day observation period. All surviving animals were necropsied at the end of the observation period.
No deaths occurred during the study. Body weight gain was not affected by treatment. A/G staining was noted in all animals within the 6-hour observation period. In-life observations also included alopecia and unkempt coat. At necropsy, macroscopic examination of main organs showed lung discoloration in seven animals.
As the acute oral LD50 was found to be greater than 5000 mg/kg b.w. under the conditions of the test, MRD-83-207 is not classified according to the criteria of Annex VI to Directive 67/548/EEC and CLP Regulation 1272/2008.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
![ECHA](/o/diss-blank-theme/images/factsheets/A-REACH/factsheet/echa_logo.png)