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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
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EC number: 203-931-2 | CAS number: 112-05-0
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Eye irritation
Administrative data
- Endpoint:
- eye irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Study period:
- 1969
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- abstract
Cross-referenceopen allclose all
- Reason / purpose for cross-reference:
- reference to same study
Reference
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- other information
- Study period:
- 1969
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- abstract
- Reason / purpose for cross-reference:
- reference to same study
- Reason / purpose for cross-reference:
- reference to same study
- Reason / purpose for cross-reference:
- reference to same study
- Principles of method if other than guideline:
- acute oral toxicity test
- GLP compliance:
- not specified
- Test type:
- standard acute method
- Limit test:
- no
- Species:
- rat
- Strain:
- other: Holtzman
- Sex:
- male
- Route of administration:
- oral: unspecified
- Vehicle:
- not specified
- Doses:
- not stated
- No. of animals per sex per dose:
- no data
- Control animals:
- not specified
- Sex:
- male
- Dose descriptor:
- LD50
- Effect level:
- > 9 040 mg/kg bw
- Conclusions:
- Under the conditions of this study the LD50 in rats was >9040 mg/kg bw.
- Executive summary:
Male Holtzman rats (number unspecified) were exposed orally to a single dose of the test substance. The LD50 was > 9040 mg/kg bw (Emery Industries, 1969).
- Reason / purpose for cross-reference:
- reference to same study
Reference
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- other information
- Study period:
- 1969
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- abstract
- Reason / purpose for cross-reference:
- reference to same study
- Reason / purpose for cross-reference:
- reference to same study
- Reason / purpose for cross-reference:
- reference to same study
- Principles of method if other than guideline:
- acute dermal toxicity test
- GLP compliance:
- not specified
- Test type:
- standard acute method
- Limit test:
- no
- Species:
- rabbit
- Strain:
- other: albino (not further specified)
- Sex:
- not specified
- Type of coverage:
- not specified
- Vehicle:
- not specified
- Duration of exposure:
- not stated
- Doses:
- maximum dose: 9.04 g, other doses not stated
- No. of animals per sex per dose:
- no data
- Control animals:
- not specified
- Dose descriptor:
- LD50
- Effect level:
- > 9 040 mg/kg bw
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- Under the conditions of this study the dermal LD50 was > 9.04 g/kg bw. The single application was irritating to the skin.
- Executive summary:
The dermal LD50 in albino rabbits was > 9.04 g/kg bw (no further details). The exposure was irritating to the skin, causing erythema and edema, initially followed by desquamation, coriaceousness and fissuring (Emery Industries, 1969).
Local irritation of undiluted material: erythema and oedema, followed by desquamation, coriaceousness, and fissuring of the skin. These effects were more marked in the highest dose group.
- Reason / purpose for cross-reference:
- reference to same study
Reference
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Study period:
- 1969
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- abstract
- Reason / purpose for cross-reference:
- reference to same study
- Reason / purpose for cross-reference:
- reference to same study
- Reason / purpose for cross-reference:
- reference to same study
- Principles of method if other than guideline:
- testing for irritation/corrosion of the skin
- GLP compliance:
- not specified
- Species:
- rabbit
- Strain:
- other: albino
- Type of coverage:
- not specified
- Preparation of test site:
- not specified
- Vehicle:
- unchanged (no vehicle)
- Controls:
- not specified
- Duration of treatment / exposure:
- no data
- Observation period:
- no data
- Number of animals:
- no data
- Irritant / corrosive response data:
- Dermal irritation was produced, characterized by erythema and edema initially followed by desquamation, coriaceousness, and fissuring. These signs were more marked in the highest dosage group.
- Conclusions:
- Data presented in this report are insufficient for a definite interpretation of the results.
- Executive summary:
Testing for irritation of the skin in rabbits with the undiluted test item (EMFAC 1202 Pelargonic acid) produced dermal irritation increasing with dosage (Emery, 1969).
Data source
Referenceopen allclose all
- Reference Type:
- other company data
- Title:
- Unnamed
- Year:
- 1 969
- Report date:
- 1969
- Reference Type:
- publication
- Title:
- Unnamed
- Year:
- 1 944
- Report date:
- 1944
Materials and methods
- Principles of method if other than guideline:
- Method: testing for irritation of the eye
Scoring according to Draize et al., 1944 - GLP compliance:
- no
Test material
- Reference substance name:
- Nonanoic acid
- EC Number:
- 203-931-2
- EC Name:
- Nonanoic acid
- Cas Number:
- 112-05-0
- Molecular formula:
- C9H18O2
- IUPAC Name:
- nonanoic acid
- Details on test material:
- - Name of test material (as cited in study report): EMFAC 1202 Pelargonic acid
Constituent 1
Test animals / tissue source
- Species:
- rabbit
- Strain:
- other: albino
Test system
- Vehicle:
- not specified
- Controls:
- not specified
- Amount / concentration applied:
- Amount applied: 91 mg
- Duration of treatment / exposure:
- not stated
- Observation period (in vivo):
- do data
- Number of animals or in vitro replicates:
- no data
- Details on study design:
- Comment: not rinsed
SCORING SYSTEM:
- In this report of Emery (1969) it is stated that the evaluation of the eye injury data was based upon the method of Draize. The authors refer to an unpublished reference of the "Association of Food and Drug Officials of the United States". As the presentation of the results by Emery (1969) is in accordance with the scoring system presented by Draize et al. (1944), it is assumed that this scoring system was the basis for the evaluation of the ocular lesions. The scoring system of Draize et al. (1944) is presented below. The scores are comparable to the scores of the OECD TG 405.
- Readings usually made at 1, 24 and 48 hours after instillation of the agent into the eye as well as after 96 hours if residual injury is present.
Results and discussion
Any other information on results incl. tables
"Marked irritation": iritis, conjunctivitis, corneal opacity. No further data
Applicant's summary and conclusion
- Interpretation of results:
- study cannot be used for classification
- Conclusions:
- Data presented in this report are insufficient for a definite interpretation of the results.
- Executive summary:
The test item was applied to the eyes of albino rabbits and produced marked irritation, including signs as iritis, conjunctivitis and corneal opacity (Emery, 1969).
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