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Diss Factsheets
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EC number: 203-509-8 | CAS number: 107-66-4
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
A valid oral toxicity study according OECD 401 is available that shows an LD50 of > 2000 mg/kg bw.
In a valid in-vitro corrosion test according OECD TG 431, dibutyl hydrogen phosphate was corrosive. Therefore an acute inhalation and dermal toxicity study does not need to be conducted according REACH Annex VII column 2.
Key value for chemical safety assessment
Acute toxicity: via oral route
Link to relevant study records
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: scientifically acceptable and sufficient documented
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 401 (Acute Oral Toxicity)
- Principles of method if other than guideline:
- 5 male and 5 female rats were administered a single dose of dibutyl hydrogen phosphate per gavage. Animals were observed for mortality, body weight and clinical signs. A gross necropsy was performed on animals sacrificed at the end of the study.
- GLP compliance:
- yes
- Test type:
- standard acute method
- Limit test:
- yes
- Species:
- rat
- Strain:
- other: Crj:CD(SD)
- Sex:
- male/female
- Route of administration:
- oral: gavage
- Vehicle:
- not specified
- Doses:
- 2000 mg/kg bw
- No. of animals per sex per dose:
- 5 males and 5 females/dose
- Control animals:
- no
- Key result
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 2 000 mg/kg bw
- Remarks on result:
- other: No deaths occurred
- Mortality:
- none
- Clinical signs:
- other: During the course of the study, a decrease in locomotor activity, deep and slow respiration, blepharoptosis and blotted fur with urine on the lower abdomen were observed in males and females, and lacrimation and red urine were additionally observed in som
- Gross pathology:
- No macroscopic abnormalities were seen in pathological examination for both male and female groups.
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- LD50 > 2000 mg/kg bw (rats, male and female).
- Executive summary:
Five male and five female rats were administered a single dose of dibutyl hydrogen phosphate per gavage. Animals were observed for mortality, body weight and clinical signs. A gross necropsy was performed on animals sacrificed at the end of the study.
During the course of the study, a decrease in locomotor activity, deep and slow respiration, blepharotosis and blotted fur with urine on the lower abdomen were observed in males and females, and lacrimation and red urine were additionally observed in some rats.
Body weight gain was slightly suppressed on the following day of treatment in many rats. No deaths occurred, and no macroscopic abnormalities were seen in pathological examination for both male and female groups.
LD50 > 2000 mg/kg bw (rats, male and female)
Reference
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed
- Dose descriptor:
- discriminating dose
- Value:
- 2 000 mg/kg bw
- Quality of whole database:
- The materials/methods and results are described in detail und are sufficient for evaluation.
Acute toxicity: via inhalation route
Endpoint conclusion
- Endpoint conclusion:
- no study available
Acute toxicity: via dermal route
Endpoint conclusion
- Endpoint conclusion:
- no study available
Additional information
In the oral toxicity key study of dibutyl hydrogen phosphate 5 male and 5 female rats were administered a single dose of 2000 mg/kg bw per gavage (OECD TG 401). Animals were observed for mortality, body weight and clinical signs. A gross necropsy was performed on animals sacrificed at the end of the study.
No deaths occurred, and no macroscopic abnormalities were seen in pathological examination for both male and female groups.
In the acute oral toxicity study from a secondary source, in rats the oral LD50 is > 3200 mg/kg bw.
No acute inhalation and dermal toxicity study was conducted for animals welfare reasons, because dibutyl hydrogen phosphate is corrosive according to a valid in-vitro corrosion test following OECD 431.
Justification for classification or non-classification
In the acute oral toxicity study an oral LD50 > 2000 mg/kg bw (discriminating dose) was found.
No acute inhalation and dermal toxicity study was conducted for animals welfare reasons, because dibutyl hydrogen phosphate is corrosive according a valid in-vitro corrosion test following OECD 431.
According to CLP classification criteria (Regulation (EC) No 1272/2008) a classification is not justified.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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