Registration Dossier
Registration Dossier
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EC number: 208-704-1 | CAS number: 538-75-0
Skin sensitisation
Administrative data
- Endpoint:
- skin sensitisation
- Remarks:
- in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
Data source
Reference
- Reference Type:
- secondary source
- Title:
- Dicyclohexylcarbodiimide identification
- Author:
- Institut für Arbeitsschutz der Deutschen Gesetzlichen Unfallversicherung (IFA)
- Year:
- 2 012
- Bibliographic source:
- Gestis data base
Materials and methods
- Principles of method if other than guideline:
- Not known
- GLP compliance:
- not specified
- Type of study:
- not specified
Test material
- Reference substance name:
- Dicyclohexylcarbodiimide
- EC Number:
- 208-704-1
- EC Name:
- Dicyclohexylcarbodiimide
- Cas Number:
- 538-75-0
- Molecular formula:
- C13H22N2
- IUPAC Name:
- N,N'-dicyclohexylcarbodiimide
Constituent 1
In vivo test system
Test animals
- Species:
- mouse
- Strain:
- not specified
- Sex:
- not specified
Results and discussion
Any other information on results incl. tables
Sensitizing actions of DCC to humans were demonstrated by several well-documented cases, in particular concerning accidental contamination of the skin.
In an experiment recently carried out on various strains of mice (mouse ear swelling test), the maximum non-irritative concentration (0.1 % solution in acetone) and the minimum irritative concentration (0.3 %) were initially tested on both sides of the outer ear. These concentrations were independent of the animal strain used. The following examination of the potential to sensitize provided distinct
differences for the sensitivity of the strains which were genetically related (dependent on the haplotype). Cross reactivity for DCC could be detected only on animals sensitized to diisopropylcarbodiimide.
It was derived from a further study on mice that physical stress (here: limitation of movement) can decrease the "threshold concentration" for sensitization.
Applicant's summary and conclusion
- Interpretation of results:
- sensitising
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- The substance is officially classified as skin sensitiser.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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