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Diss Factsheets
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EC number: 239-784-6 | CAS number: 15687-27-1
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Link to relevant study record(s)
Description of key information
Key value for chemical safety assessment
Additional information
A review provided information on the absorption and distribution of the test substance, investigated in mice, rats, and dogs after oral administration for periods of up to 6 months (Adams, 1969). The test material administered orally was rapidly absorbed from the intestine and to a lesser, though significant, extent from the stomach. Four metabolites of the test substance were detected in rabbit plasma, 3 of these were also in rat plasma, but none were detected in dog plasma. Distribution studies with 14C-labeled test material revealed that oral repeated dosing of rats led to some accumulation of radioactivity in the adrenals, ovaries, thyroid, skin, and fat, without structure or function being affected. Dogs, however, had high levels only in bile.
The inversion of the test substance was investigated in the rat H4IIE and human Hep G2 hepatoma cell line, to determine the suitability for future use considering possible inversion properties (Menzel-Soglowek, 1992). The test substance was incubated under varying conditions with the cell lines for 5 days and samples were taken ± every 24 hours. The test substance and metabolites were quantified with HPLC. A decrease in serum concentration shows an increase in elimination rate of the R-form of the test substance and an increase in formation of the S-form of test substance. Additonally, the study shows that the test substance (R-form) may be converted to its antipode (S-form) in the rat H4IIE and human Hep G2 hepatoma cell line, but no conversion of the S-form takes place.
PBTK modelling was used to simulate the concentration-time profile of the test substance and estimate the distribution of the test material in the portal vein, hepatic vein and in general circulation after oral gavage administration (Mielke, 2011). The concentration used in the model was 94 mg/kg and considered to be administered orally by gavage with an assumed absorption of 55%. Elimination was not included in the model. The estimated concentrations were 141.6 mg/L in the portal vein, hepatic vein and blood circulation.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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