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Diss Factsheets
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EC number: 228-846-8 | CAS number: 6362-80-7
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
PBT assessment
Administrative data
PBT assessment: overall result
- PBT status:
- the substance is PBT / vPvB
- Justification:
Persistence: The test item is considered to be P but not vP. The inherent biodegradability of the test material was assessed according to OECD guideline 302 C. The test item attained 75%, 83% and 34% degradation with a mean of 64% degradation calculated from oxygen consumption values after 28 days. Under the conditions of this study, as the substance attained >20 % over 28 days the substance can be considered as inherently biodegradable. However, in accordance with REACH Guidance on information requirements and chemical safety assessment, Chapter R11: PBT Assessment, as the substance did not attain 70 % degradation over 14 days this is a clear indication that the substance will not biodegrade and should be regarded as persistent. Furthermore, the hydrolysis as a function of pH of the test item was assessed according to OECD guideline 111. The half-life for hydrolysis was considered to be > 1 year which also indicates that the substance should be classified as persistent.
Bioaccumulation: The test item is considered to be B but not vB based on 2,000 < BCF ≤ 5,000 L/kg, as identified in Annex XIII criteria of REACH. The bioaccumulative potential of the test item was assessed according to GLP and to the test method relating to New Chemical Substances (Kanpogyo No. 5, Yakuhatsu No. 615, 49 Kikyoku No. 392, 1974; partially revised 1998). The concentration rate (BCF) was 427-3330 at high concentration and 423-4410 at low concentration. Therefore, under the conditions of this study the test item should be considered as bioaccumulative but not very bioaccumulative.
Toxicity: The test item is considered to be T. In a repeat dose toxicity study, the no-effect level of the test item was found to be less than 45 mg/kg/day in males and 45 mg/kg/day in females because of effects on the liver. As such, the substance should be classified as Specific Target Organ Toxicity Repeated Exposure Category 2 in accordance with Regulation 1272/2008. Furthermore, in accordance with Regulation 1272/ 2008, the substance meets the criteria as an acute aquatic hazard category 1 as the EC50 and LC50 results from 3 acute, aquatic toxicity studies are ≤ 1 mg/L (for fish, the 96-Hour LC50 based on the time weighted mean was >0.092 mg/L; for algae, the 72-hour EC50 was > 0.059 mg/L (maximum attainable concentration); for Daphnia, the 48-h EC50 was found to be 0.057 mg/L). The substance also meets the criteria as a chronic aquatic hazard category 1 as the substance is not readily biodegradable, the BCF value was experimentally determined as 4410 and the Log Pow has been determined as 6.2
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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