Registration Dossier
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EC number: 268-452-3 | CAS number: 68092-28-4
Short-term toxicity to aquatic invertebrates
Administrative data
Link to relevant study record(s)
Description of key information
EC50 (48h) = 4.1 mg/l based on mean measured concentrations
Key value for chemical safety assessment
Fresh water invertebrates
Fresh water invertebrates
- Effect concentration:
- 4.1 mg/L
Additional information
The acute toxicity potential of the test material to Daphnia magna was assessed in the key study in accordance with the standardised guidelines OECD 202 and EU Method C.2 under GLP conditions. It was assigned a reliability score of 1 in accordance with the criteria set forth in Klimisch (1997).
Due to the low aqueous solubility and complex nature of the test material, it was prepared as a Water Accommodated Fraction (WAF).
Following preliminary range-finding tests, twenty daphnids (4 replicates of 5 animals) were exposed to WAFs of the test material over a range of nominal loading rates of 1.0, 1.8, 3.2, 5.6 and 10 mg/L for 48 hours at a temperature of approximately 21 °C under static test conditions. The number of immobilisedDaphniaand any adverse reactions to exposure were recorded after 24 and 48 hours.
Chemical analysis was conducted on the loading rate at the No Observed Effect Concentration (NOEC) and above. Analysis of the 3.2, 5.6 and 10 mg/L loading rate WAFs at 0 and 48 hours gave measured concentrations of near nominal.
Under the conditions of this study, exposure of Daphnia magna to the test material gave a 48 hour EC50 value based on mean measured concentrations of 4.1 mg/L; 95 % confidence limits 3.1 - 5.5 mg/L.
As a result of the EC50 value the test material does not require a classification for Acute Aquatic Toxicity in accordance with EU criteria.
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